6 documents found, page 1 of 1
A novel platinum complex containing a piplartine derivative exhibits enhanced c...
Oliveira, Maiara de Souza; Barbosa, Marília Imaculada Frazão; Souza, Thiago Belarmino de; Moreira, Diogo Rodrigo de Magalhães; Martins, Felipe TerraPiplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigat...
Reactive nitrogen/oxygen species production by nitro/nitrosyl supramolecular ru...
Barbosa, Marília Imaculada Frazão; Gimenez Parra, Gustavo; Correa, Rodrigo de Souza; Sampaio, Renato Neiva; Magno, Lais Nogueira; Silva, Rodrigo CostaThis manuscript reports on new nitro/nitrosyl Ru-based complexes, which were synthesized with the purpose of using them as precursors to obtain supramolecular ruthenium porphyrin species ({TPyP[Ru (NO2)(5,50-Mebipy)2]4}(PF6)4) and ({TPyP[Ru(NO)(5,50-Mebipy)2]4}(PF6)12). The photochemical and photophysical properties of these porphyrin species were investigated. Results show that the complex containing nitrite i...
Busca por novos metalofármacos contra doenças negligenciadas (malária, doença d...
Barbosa, Marília Imaculada FrazãoFinanciadora de Estudos e Projetos; Leishmaniasis, Chagas disease and malaria are neglected parasitic diseases responsible for high mortality in tropical low-income countries. Due to the lack of vaccines and of safe, effective and affordable treatments, there is an urgent need to reinforce the existing therapeutic arsenal against these diseases. Many potential drugs have been investigated for these diseases, in...
Complexos carbonílicos de rutênio. De um gás tóxico a uma droga com potencial a...
Barbosa, Marília Imaculada FrazãoFinanciadora de Estudos e Projetos; In this work ruthenium carbonyl complexes were synthesized and characterized which allowed an interesting spectroscopic and structural study as well as preliminary in vitro antitumor activity assays. Thus, the interests in the transition metal carbonyls, which carry and liberate CO, are also emerging as a pharmacological tool to mimic the bioactivity of endogenously generated...
Ruthenium(II) complexes with hydroxypyridinecarboxylates : screening potential ...
Barbosa, Marília Imaculada Frazão; Correa, Rodrigo de Souza; Pozzi, Lucas Vinícius dos Santos; Pavan, Fernando Rogério; Leite, Clarice Queico FujimuraThree promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), t...
Antiparasitic activities of novel ruthenium/lapachol complexes.
Barbosa, Marília Imaculada Frazão; Corrêa, Rodrigo de Souza; Oliveira, Katia Mara de; Rodrigues, Claudia; Ellena, Javier AlcidesUniversidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil; Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil; Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil; Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil; Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, ...