13 documents found, page 1 of 2
Avaliação do risco de desenvolver diabetes mellitus tipo 2 em estudantes do cur...
Figueiredo, Monalisa Feliciano; Maia Filho, Pedro Aurio; Almeida Filho, Tarcísio Paulo de; Laurentino, Marília Rocha; Barbosa, Maritza CavalcanteO Diabetes mellitus (DM) é uma doença metabólica de etiologia múltipla, caracterizada por uma hiperglicemia decorrente de uma alteração na secreção ou ação da insulina. O DM tipo 1 (DM1) está relacionado com a deficiência de insulina resultante da destruição das células-β do pâncreas; o DM tipo 2 (DM2) resulta de um processo fisiopatológico que culmina com a resistência à insulina, sendo o DM2 considerado um pr...
Wernicke’s encephalopathy in a patient with non- Hodgkin’s lymphoma post-Autolo...
Leitão, João Paulo de Vasconcelos; Lemes, Romélia Pinheiro Gonçalves; Barbosa, Maritza Cavalcante; Araújo, Beatriz Stela Gomes de Souza PitombeiraWernick’s Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predisposed t...
Prolonged response to recombinant human erythropoietin treatment in patients wi...
Moura, Anna Thawanny Gadelha; Duarte, Fernando Barroso; Barbosa, Maritza Cavalcante; Santos, Talyta Ellen de Jesus dosOBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. METHODS: This was a retrospective cohort study of 36 patients diagnosed with MDS and treated with EPO alfa at 30,000 to 60,000 IU per week. Clinical data were...
Prolonged response to recombinant human erythropoietin treatment in patients wi...
Moura, Anna Thawanny Gadelha; Duarte, Fernando Barroso; Barbosa, Maritza Cavalcante; Santos, Talyta Ellen de Jesus dosOBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. METHODS: This was a retrospective cohort study of 36 patients diagnosed with MDS and treated with EPO alfa at 30,000 to 60,000 IU per week. Clinical data were...
Presence of new mutations in the TP53 gene in patients with low-risk myelodyspl...
Duarte, Fernando Barroso; Lemes, Romélia Pinheiro Gonçalves; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteBackground Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...
Interleukin-8 and nuclear factor kappa B are increased and positively correlate...
Matos, Anacélia Gomes de; Ribeiro Junior, Howard Lopes; Borges, Daniela de Paula; Okubo, Bruno Memória; Sousa, Juliana Cordeiro deThe pathogenesis of myelodysplastic syndromes (MDS) is complex and depends on the interaction between aberrant hematopoietic cells and their microenvironment, probably including aberrations in cytokines and their signaling pathways. To evaluate interleukin-8 (IL-8) plasma levels and nuclear factor kappa B (NF-kB) in patients with MDS and to test possible correlation between IL-8 and NFKb, a total of 45 individu...
Association of oxidative stress and DNA damage with grafting time in patients w...
Santos, Thayna Nogueira dos; Duarte, Fernando Barroso; Maia Filho, Pedro Aurio; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteSANTOS, Thayna Nogueira .; The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage i...
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle...
Moreira, Juliane Almeida; Laurentino, Marília Rocha; Machado, Rosângela Pinheiro Gonçalves; Barbosa, Maritza Cavalcante; Gonçalves, Ronaldo PinheiroObjective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA indiv...
Methemoglobin measure in adult patients with sickle-cell anemia : influence of ...
Laurentino, Marilia Rocha; Carvalho, Teresa Maria de Jesus Ponte; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteIntroduction: Hemoglobin S (HbS) is unstable hemoglobin that easily oxidizes, causing methemoglobin (MetHb) increased production in patients with sickle-cell anemia (SCA). Objectives: To determine MetHb levels and the influence of hydroxyurea (HU) therapy on this marker in patients with SCA. Materials and methods: Blood samples from 53 patients with SCA at the steady-state, with and without HU therapy, and 30 h...
Tumor suppressor p53 protein expression : prognostic significance in patients w...
Duarte, Fernando Barroso; Gonçalves, Romelia Pinheiro; Barbosa, Maritza Cavalcante; Rocha Filho, Francisco Dário; Santos, Talyta Ellen de Jesus dosBackground: At the time of diagnosis, more than 50% of patients with myelodysplastic syn- drome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability. Objective: To evalua...