3 documents found, page 1 of 1
Validation of an HPLC method for the determination of dibucaine encapsulated in...
Barbosa, Raquel de M.; Klassen, Aline; Marcato, Priscyla D.; Franz-Montan, Michelle; Grillo, Renato [UNESP]; Fraceto, Leonardo F. [UNESP]Made available in DSpace on 2022-04-29T07:12:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-11-27; Dibucaine (DBC), used mainly in topical formulations, is one of the most potent long-acting local anesthetics, but is also one of the more toxic. Recently, solid lipid nanoparticles and nanostructured lipid carriers have been attracting attention as promising drug delivery carriers. This study develops ...
Lipid-Polymeric Films: Composition, Production and Applications in Wound Healin...
Souto, Eliana B.; Yoshida, Cristiana M. P.; Leonardi, Gislaine R.; Cano, Amanda; Sanchez-Lopez, Elena; Zielińska, Aleksandra; Viseras, CésarThe use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanic...
Loading of 5-aminosalicylic in solid lipid microparticles (SLM): Solubility scr...
Silveira, Elisânia F.; Rannier, Lucas; Nalone, Luciana; da Silva, Classius F.; Chaud, Marco V.; Barbosa, Raquel de M.; Junior, Ricardo L. C. A.5-Aminosalicylic acid (5-ASA), the active moiety of sulphasalazine, is the most commonly used drug for treating patients with inflammatory bowel disease (IBD). Its bioavailability is low, i.e. 20--30\% upon oral administration and 10--35\\% by rectal administration. As the extent of 5-ASA absorption is very much dependent on the time-length, the drug is retained in the colon, a way to increase drug retention is...