Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) andradiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable.Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy andchemotherapy-associated xerostomia. Th...
BARBOSA, Sabrina Carneiro Melo. Efeito protetor da amifostina sobre a mucosite oral, via inibição de TNF-a, IL-1b e NOSi, e sobre a hipossalivação induzidas por 5-fluorouracil em hamsters . 2011. 108 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2011.; Oral mucositis (OM) is a common complication and limitation of cancer chemotherapy. Amifostine (AM...