2 documents found, page 1 of 1
Study of pre-formulation and development of solid lipid nanoparticles containin...
Cavendish, Mariana; Nalone, Luciana; Barbosa, Thallysson; Barbosa, Raquel; Costa, Salvana; Nunes, Rogéria; da Silva, Classius Ferreira; Chaud, Marco V.The aim of this work was to study the physicochemical characterization of lipid matrices composed of cetyl palmitate (CP)/perillyl alcohol (PA) and develop preliminary studies of SLN for potential application in cancer treatment. The pre-formulation was submitted to recrystallization process (heatingcooling) in a concentration of CP/AP (F1 1:0; F2 1:9; F3 1:3; and F4 1:1). The characterization showed TG present...
Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical char...
Andrade, Luciana Nalone; Marques, Conrado; Barbosa, Thallysson; Santos, Rafael; Chaud, Marco Vinícius; Ferreira da Silva, ClassiusPraziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SL...