4 documents found, page 1 of 1
Use of remdesivir in patients with COVID-19: a systematic review and meta-analysis
Tanni,Suzana E; Silvinato,Antonio; Floriano,Idevaldo; Bacha,Hélio A; Barbosa,Alexandre Naime; Bernardo,Wanderley MABSTRACT Objective: Studies in the literature regarding the use of remdesivir to treat COVID-19 patients have shown conflicting results. This study sought to answer questions related to the use of remdesivir for the treatment of patients hospitalized with moderate to severe COVID-19. Methods: This was a systematic review and meta-analysis including phase 3 randomized clinical trials (RCTs) and observational coh...
Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: ...
Menegali,Bruno Thizon; Schuelter-Trevisol,Fabiana; Barbosa,Alexandre Naime; Izidoro,Talita Menegali; Feurschuette,Otto Henrique MayAbstract The use of coronavirus disease 2019 RNA vaccines in pregnant women led to reports on the first cases of newborns with antibodies to sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a phenomenon that was unknown when using immunizations with inactivated viruses. Thus, this study aimed to report a case of passive anti-SARS-CoV-2 immunity in a newborn through immunoprophylaxis of a pregnant w...
A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera...
Barbosa,Alexandre Naime; Boyer,Leslie; Chippaux,Jean-Philippe; Medolago,Natalia Bronzatto; Caramori,Carlos Antonio; Paixão,Ariane GomesAbstract Background Envenomation caused by multiple stings from Africanized honeybees Apis mellifera constitutes a public health problem in the Americas. In 2015, the Brazilian Ministry of Health reported 13,597 accidents (incidence of seven cases per 100,000 inhabitants) with 39 deaths (lethality of 0.25%). The toxins present in the venom, which include melittin and phospholipase A2, cause lesions in diverse o...
The absence of the human platelet antigen polymorphism effect on fibrosis progr...
Picelli,Natália; Tanikawa,Aline Aki; Grotto,Rejane Maria Tommasini; Silva,Giovanni Faria; Barbosa,Alexandre Naime; Ferrasi,Adriana CamargoAbstractINTRODUCTION:Hepatic fibrosis progression in patients with chronic hepatitis C virus infections has been associated with viral and host factors, including genetic polymorphisms. Human platelet antigen polymorphisms are associated with the rapid development of fibrosis in HCV-monoinfected patients. This study aimed to determine whether such an association exists in human immunodeficiency virus-1/hepatiti...