9 documents found, page 1 of 1
Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autolog...
Leitão,João Paulo de Vasconcelos; Lemes,Romélia Pinheiro Gonçalves; Barbosa,Maritza Cavalcante; Araújo,Beatriz Stela Gomes de Souza PitombeiraSUMMARY Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predi...
Relevance of prognostic factors in the decision-making of stem cell transplanta...
Duarte,Fernando Barroso; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza Cavalcante; Kaufman,Jacques; Vasconcelos,João Paulo deABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to discuss the factors that can guide the decision-making on referring or not a patient to HSCT. Three cases of ...
Association of oxidative stress and DNA damage with grafting time in patients w...
Santos,Thayna Nogueira dos; Duarte,Fernando Barroso; Maia Filho,Pedro Aurio; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza CavalcanteABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were per...
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle...
Moreira,Juliane Almeida; Laurentino,Marília Rocha; Machado,Rosângela Pinheiro Gonçalves; Barbosa,Maritza Cavalcante; Gonçalves,Ronaldo PinheiroObjective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA indivi...
Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alph...
Laurentino,Marília Rocha; Maia Filho,Pedro Aurio; Barbosa,Maritza Cavalcante; Bandeira,Izabel Cristina Justino; Rocha,Lilianne Brito da SilvaBackground: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha levels remains unknown. Objective: The aim of this stud...
Tumor suppressor p53 protein expression: prognostic significance in patients wi...
Duarte,Fernando Barroso; Gonçalves,Romelia Pinheiro; Barbosa,Maritza Cavalcante; Rocha Filho,Francisco Dário; Santos,Talyta Ellen de Jesus dosBACKGROUND: At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability.OBJECTIVE: To evaluate ...
Methemoglobin measure in adult patients with sickle-cell anemia: influence of h...
Laurentino,Marilia Rocha; Carvalho,Teresa Maria de Jesus Ponte; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza Cavalcante; Santos,Thayna Nogueira dosIntroduction: Hemoglobin S (HbS) is unstable hemoglobin that easily oxidizes, causing methemoglobin (MetHb) increased production in patients with sickle-cell anemia (SCA). Objectives: To determine MetHb levels and the influence of hydroxyurea (HU) therapy on this marker in patients with SCA. Materials and methods: Blood samples from 53 patients with SCA at the steady-state, with and without HU therapy, and 30 h...
Impact of iron overload on interleukin-10 levels, biochemical parameters and ox...
Barbosa,Maritza Cavalcante; Santos,Talyta Ellen Jesus dos; Souza,Geane Félix de; Assis,Lívia Coêlho de; Freitas,Max Victor CariocaOBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients. METHODS: A cross-sectional study was performed of 30 patients with molecular diagnosis of sickle cell anemia. Patients were stratified into two groups, according to the presence of iron overload: Iron overload (n = 15) a...
Serum concentrations of nitrite and malondialdehyde as markers of oxidative str...
Petrola,Maria Juracy; Castro,Alana Joselina Montenegro de; Pitombeira,Maria Helena da Silva; Barbosa,Maritza Cavalcante; Quixadá,Acy Telles de SouzaBACKGROUND: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic myeloid leukemia, is constitutively activated thus inducing the production of reactive oxygen species. Of particular relevance is the fact that an increase in reacti...