4 documents found, page 1 of 1
Glucose metabolism as a potential therapeutic target in Cytarabine-resistant ac...
Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Barbosa-Matos, Catarina; Granja, Sara; Reis, Rui Manuel; Queirós, Odília; Ko, Young H.Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target. Resist...
Portuguese propolis antitumoral activity in melanoma involves ROS production an...
Oliveira, Rafaela Dias; Celeiro, Sónia Pires; Barbosa-Matos, Catarina; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, MartaMelanoma is the most aggressive and life-threatening skin cancer type. The melanoma genome is the most frequently mutated, with the <i>BRAF</i> mutation present in 40–60% of melanoma cases. <i>BRAF</i>-mutated melanomas are characterized by a higher aggressiveness and progression. Adjuvant targeted treatments, such as BRAF and MEK inhibitors, are added to surgical excision in <i>BRAF</i>-mutated metastatic mela...
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promot...
Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, ToineIn response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Aspergillus fumigatus. Using pharmacological and genetic tools, we reveal a molecular link between calcium sequestrat...
Rational identification of a colorectal cancer targeting peptide through phage ...
Ferreira, Débora; Silva, Ana P.; Nóbrega, Franklin Luzia; Martins, Ivone M.; Barbosa-Matos, Catarina; Granja, Sara; Martins, Sandra F.; Baltazar, FátimaColorectal cancer is frequently diagnosed at an advanced stage due to the absence of early clinical indicators. Hence, the identification of new targeting molecules is crucial for an early detection and development of targeted therapies. This study aimed to identify and characterize novel peptides specific for the colorectal cancer cell line RKO using a phage-displayed peptide library. After four rounds of sele...