15 documents found, page 1 of 2
Frequency, characteristics and predictors oc central and peripheral neurologica...
Costa, R. Pereira da; Bandeira, Matilde; Silvério-António, Manuel; Lopes, Ana Rita; Santos, Filipe Cunha; Pereira, Paulo J.; Raimundo, Diana BelchiorBackground: Sjogren's disease (SjD) systemic affection is being increasingly recognized. The prevalence of peripheral (PNS) and central (CNS) nervous system involvement in SjD and risk factors for these manifestations have not been clearly established. Objectives: To define the clinical characteristics of SjD patients with CNS and/or PNS involvement and to find predictors of this involvement.
PORTRESS – the PORTuguese Reuma.pt registry for Sjögren’S disease
Bandeira, Matilde; Silvério-António, Manuel; Costa, Roberto Pereira da; Lopes, Ana Rita; Santos, Filipe Cunha; Pereira, Paulo J.Aims: Sjögren's disease (SjD) is a complex disease with a wide variety of manifestations and outcomes. We recently created PORTRESS, the Portuguese SjD registry within Reuma.pt. We aim to describe this registry and characterize our national cohort. Methods: We included patients with a clinical diagnosis of SjD, registered in PORTRESS up to November 2023. Demographic, clinical, treatment, and patient-reported ou...
Sociodemographic factors and biologic therapy exposure impacting health-related...
Santos, Helena; Oliveira Henriques, Ana Rita; Canhão, Helena; Machado, Pedro M.; M. Pimentel-Santos, F.; Silva, Cândida; Lobão, BárbaraFunding Information: This work was supported by a research grant from the Portuguese Society of Rheumatology. Publisher Copyright: © The Author(s) 2025.; Psoriatic arthritis (PsA) is a very heterogeneous disease with significant impact on health-related quality-of-life (HRQoL). Our objective was to assess and identify predictors of HRQoL in a 3-year follow-up period among PsA patients. Patients with PsA include...
Added value of lymphocyte subpopulations in the classification of Sjögren's syn...
Barcelos, Filipe; Brás-Geraldes, Carlos; Martins, Catarina; Papoila, A.L.; Monteiro, Ricardo; Cardigos, Joana; Madeira, Nathalie; Alves, NunoFunding Information: The first author gratefully acknowledges Academia Cuf/José de Mello Saúde and Sociedade Portuguesa de Reumatologia for their financial support. The authors gratefully acknowledge the laboratory staff that assisted in the flow cytometry analysis. Publisher Copyright: © 2023, The Author(s).; Sjögren's Syndrome (SjS) is a chronic systemic immune-mediated inflammatory disease characterized by l...
Measuring quality of life of patients with axial spondyloarthritis for economic...
Hernandez Alava, Monica; Wailoo, Allan; Chrysanthou, Georgios; Barcelos, Filipe; van Gaalen, Floris A; Santos, Helena; Fagerli, Karen Minde; Gago, LauraObjectives To estimate the relationship between EQ5D (three levels, UK version) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) for use in the economic evaluation of health technologies for people with axial spondyloarthritis (axSpA). To compare against the relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Methods An electronic, prospective, Portuguese, nationwide,...
Association between EBV serological patterns and lymphocytic profile of SjS pat...
Barcelos, Filipe; Martins, Catarina; Monteiro, Ricardo; Cardigos, Joana; Prussiani, Tiziano; Sítima, Miguel; Alves, Nuno; Vaz-Patto, José; Branco, JaimeSjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated by T-cells. B-cells are main targets of Epstein-Barr virus (EBV) infection, a frequently-suggested trigger for SjS. We aimed to evaluate how the EBV infection modulates B and T-cell subsets in SjS, including as cont...
Populações linfocitárias no diagnóstico da Síndrome de Sjögren
Barcelos, FilipeA Síndrome de Sjögren primária (SSP) é uma doença inflamatória crónica, de origem autoimune, que se carateriza pela infiltração linfocitária e lesão das glândulas exócrinas.O diagnóstico diferencial entre uma síndrome seca de origem autoimune (SSP) ou não-autoimune (complexo Sicca) é o principal desafio no diagnóstico da SSP, tendo extrema importância no prognóstico e na terapêutica.Atualmente, os principais el...
Corneal sub-basal nerve plexus assessment and its association with phenotypic f...
Barcelos, Filipe; Hipólito-Fernandes, Diogo; Martins, Catarina; Ângelo-Dias, Miguel; Cardigos, Joana; Monteiro, Ricardo; Alves, Nuno; Vaz-Patto, JoséPurpose: To assess and compare corneal sub-basal nerve plexus morphology with circulating lymphocyte subsets, immunologic status and disease activity in Sjögren syndrome (SjS) patients. Methods: Fifty-five SjS patients, 63 Sicca patients (not fulfilling SjS criteria), 18 rheumatoid arthritis (RA) patients and 20 healthy controls (HC) were included. Systemic disease activity in SjS was assessed with the ESSDAI s...
New Perspectives of Ocular Surface Evaluation in Primary Sjögren’s Syndrome
Cardigos, Joana; Barcelos, Filipe; Carvalho, Helena; Luis, Maria Elisa; Crisostomo, Sara; Vaz-Patto, José; Alves, NunoIntroduction: The diagnosis of Primary Sjögren's Syndrome (pSS) is sometimes challenging, taking into account the clinical heterogeneity and the variability of diagnostic criteria fulfillment. This study aims to evaluate the tear meniscus (TM) and corneal sub-basal nerve plexus (SBNP) in a population with pSS. Material and Methods: Cross-sectional study of 50 patients with pSS and 20 healthy controls. Conventio...
Tear Meniscus and Corneal Sub-basal Nerve Plexus Assessment in Primary Sjögren ...
Cardigos, Joana; Barcelos, Filipe; Carvalho, Helena; Hipólito, Diogo; Crisóstomo, Sara; Vaz-Patto, José; Alves, NunoPurpose: To evaluate lower tear meniscus and corneal sub-basal nerve plexus in primary Sjögren's syndrome (pSS) and Sicca syndrome patients. Methods: Cross-sectional study of 116 patients with Sicca syndrome associated with pSS and not associated with Sjögren's syndrome (non-SS Sicca) and 20 normal control subjects. Tear meniscus height and area were measured using anterior segment optical coherence tomography;...