12 documents found, page 1 of 2
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression...
Macedo, Danielle; Chaves Filho, Adriano José Maia; Sousa, Caren Nádia Soares de; Quevedo, João; Barichello, Tatiana; Nobre Júnior, Hélio VitorianoObjectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this na...
Imipramine reverses depressive-like parameters in pneumococcal meningitis survi...
Vilela, Márcia Carvalho; Barichello, Tatiana; Milioli, Graziele; Generoso, Jaqueline S.; Cipriano, Andreza L.; Costa, Caroline S.; Moreira, Ana PaulaPneumococcal meningitis is a severe infectious disease of the central nervous system, associated with acute inflammation and might cause damage to the host, such as deafness, blindness, seizure, and learning deficits. However, infectious diseases can play a significant role in the etiology of neuropsychiatric disturbances. In this context, we evaluated depressive-like parameters; corticosterone and ACTH levels ...
Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adu...
Vilela, Márcia Carvalho; Barichello, Tatiana; Generoso, Jaqueline S.; Simões, Lutiana R.; Elias, Samuel G.; Tashiro, Michael H.; Dominguini, DiogoStreptococcus pneumoniae is a common cause of forms of bacterial meningitis that have a high mortality rate and cause long-term neurologic sequelae. We evaluated the effects of an indoleamine 2,3-dioxygenase (IDO) inhibitor on proinflammatory mediators and memory in Wistar rats subjected to pneumococcal meningitis. The animals were divided into 4 groups: sham, sham treated with IDO inhibitor, meningitis, and me...
Cannabidiol reduces host immune response and prevents cognitive impairments in ...
Barichello, Tatiana; Ceretta, Renan A.; Generoso, Jaqueline S.; Moreira, Ana Paula; Simões, Lutiana R.; Comim, Clarissa M.; Quevedo, JoãoPneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment of learning and memory. The aim of this study was to evaluate the effects of acute and extended admi...
Neonatal Escherichia coli K1 meningitis causes learning and memory impairments ...
Vilela, Márcia Carvalho; Barichello, Tatiana; Dagostim, Valdemira S.; Generoso, Jaqueline S.; Simões, Lutiana R.; Dominguini, Diogo; Silvestre, CintiaNeonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood–brain barrier integrity in neonatal rats following E. coli K1 experimental meningitis infection and subsequent behavioural parameters in adulthood. In the hippocampus, in...
Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in n...
Teixeira, Antonio Lucio; Barichello, Tatiana; Lemos, Joelson C.; Generoso, Jaqueline S.; Cipriano, Andreza L.; Milioli, Graziele L.We verify the levels of cytokine/chemokine, myeloperoxidase activity, oxidative stress and disruption of BBB in hippocampus and cortex of the neonate Wistar rats after meningitis by S. agalactiae. In the hippocampus the levels were increased of CINC-1 at 6 h and 12 h, IL-1β at 6, 12 and 24 h, IL-6 at 6, 24 and 96 h, IL-10 at 24, 48 and 96 h and TNF-α at 24 h and 96 h. In the cortex the CINC-1 and IL-1β levels w...
Brain–blood barrier breakdown and pro-inflammatory mediators in neonate rats su...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Moreira, Ana Paula; Costa, Caroline S.; Zanatta, Jessiele R.; Simões, Lutiana R.Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured bra...
Gut microbiota, bacterial translocation, and interactions with diet : pathophys...
Slyepchenko, Anastasiya; Maes, Michael; Jacka, Felice N.; Köhler, Cristiano A.; Barichello, Tatiana; McIntyre, Roger S.; Berk, Michael; Grande, IriaBackground: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hy- pothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and re-sultant bacterial translocation add a new element to the bi- directional interactions of the gut-brain axis; new evidence impli...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...
Environmental enrichment restores cognitive deficits induced by experimental ch...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Dagostin, Caroline S.; Simões, Lutiana R.; Vilela, Márcia C.; Comim, Clarissa M.To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers unt...