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Portal cd4+ and cd8+ t lymphocyte correlate to intensity of interface hepatitis...

Viso, Ana Teresa Rodriguez; Barbosa, Thaís de Castro; Yamamoto, Lídia; Pagliari, Carla; Fernandes, Elaine Raniero; Brasil, Roosecelis Araújo

BACKGROUND: The pathogenesis of chronic hepatitis C is still a matter of debate. CD4+ and CD8+ T lymphocytes (TL) are typically observed within the portal and periportal spaces of affected livers, but their functional role in hepatitis C progression has not been fully elucidated. METHODS: CD4+ and CD8+ TL were quantified by immunohistochemistry in portal and periportal spaces of 39 liver biopsies from patients ...

Date: 2007   |   Origin: Oasisbr

Patients with chronic hepatitis C and normal transaminases

Pereira, Haydée Marina do Valle; Cavalheiro, Norma de Paula; Tengan, Fátima Mitiko; Melo, Carlos Eduardo; Mello, Evandro Sobroza; Barone, Antônio Alci

Hepatitis C virus infection evolves progressively persisting in the majority of patients (85%). Most patients have high ALT (alanine aminotransferase) levels and approximately 25% normal ALT. The latter are usually female and there is no association between genotype and severity of hepatic lesion. Histologic analysis usually shows small lesion and absence or low amount of fibrosis, despite cirrhosis having been...

Date: 2005   |   Origin: Oasisbr

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