Objective: Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals. Materials and methods: Sixteen Swiss mice received a standard diet (DP) or high- -fat diet (DH) for 10 weeks. Results: Although the DP group had greater water (p < 0.01) and feed (p < 0.001) consumption, the DH group...
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In this study, the ethanol extract of the inner bark of the Syderoxylum obtusifolium (EESob) was tested in the model of cyclophosphamide-induced hemorrhagic cystitis. Male Wistar rats were submitted to the injection of cyclophosphamide, 1 h after the treatment with EESob (200 or 400 mg/kg) or vehicle. After 24 h, the urinary bladder was excised and the edema, myeloperoxidase activity and malondialdehyde formati...
Orientador: Edson Antunes; Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas; Resumo: A pancreatite aguda e uma doença inflamatória do pâncreas caracterizada por intensa necrose pancreática e efeitos sistêmicos secundários como lesão pulmonar, os quais são a principal causa da mortalidade observada nessa doença. Ha evidencia de que as fosfolipases A2 (PLA2) tem um importante pa...