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m5U54 tRNA hypomodification by lack of TRMT2A drives the generation of tRNA-der...
Pereira, Marisa; Ribeiro, Diana R.; Pinheiro, Miguel M.; Ferreira, Margarida; Kellner, Stefanie; Soares, Ana R.Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. Recen...
m5U54 tRNA hypomodification induces the generation of tRNA-derived small RNAs
Pereira, Marisa; Ribeiro, Diana R.; Kellner, Stefanie; Soares, Ana R.Transfer RNAs (tRNAs) are the effector molecules of translation and are also a known source of small non-coding RNAs collectively known as tRNA-derived small RNAs (tsRNAs). tsRNAs have regulatory functions that range from translation regulation to gene expression control and cellular stress response, but what exactly triggers their formation is still under discussion. Both tRNAs and tsRNAs bear several modifica...
Lack of TRMT2A, a tRNA methyltransferase, leads to m5U54 tRNA hypomodification ...
Pereira, Marisa; Ribeiro, Diana R.; Pinheiro, Miguel M.; Ferreira, Margarida; Kellner, Stefanie; Soares, Ana R.Transfer RNAs (tRNAs) are subjected to a wide variety of post-transcriptional modifications to ensure their structural stability, correct folding, and efficient protein decoding. More specifically, modifications in the D- and T-loops of tRNAs are essential for tRNA stability. However, the biological role of the tRNA epitranscriptome in the generation of tRNA-derived small RNA fragments (tsRNAs), a class of smal...
tRNA-modifying enzyme mutations induce codon-specific mistranslation and protei...
Tavares, Joana F.; Davis, Nick K.; Poim, Ana; Reis, Andreia; Kellner, Stefanie; Sousa, Inês; Soares, Ana R.; Moura, Gabriela M. R.; Dedon, Peter C.Protein synthesis rate and accuracy are tightly controlled by the cell and are essential for proteome homoeostasis (proteostasis); however, the full picture of how mRNA translational factors maintain protein synthesis accuracy and co-translational protein folding are far from being fully understood. To address this question, we evaluated the role of 70 yeast tRNA-modifying enzyme genes on protein aggregation an...