3 documents found, page 1 of 1
Antileishmanial and immunomodulatory effect of Babassu-Loaded PLGA microparticl...
Silva, Mayara Cristina Pinto da; Brito, Jefferson Mesquita; Ferreira, Amalia dos Santos; Vale, Andre Alvares Marques; Santos, Ana Paula Azevedo dosThe immunological and the anti-Leishmania amazonensis activity of babassu-loaded poly(lactic-co-glycolic acid) [PLGA] microparticles was evaluated. The anti-Leishmania activity was evaluated against promastigotes or amastigotes forms, in Balb/c macrophages. The size of the microparticles ranged from 3 to 6.4 m, with a zeta potential of −25 mV and encapsulation efficiency of 48%. The anti-Leishmania activity of ...
Evaluation of vaccinal e ff ectiveness of preparations containing membrane anti...
Ribeiro, João G.; Ferreira, Amália S.; Macedo, Sharon R.A.; Rossi, Norton R.D.L.P.; Silva, Mayara C.P. da; Guerra, Rosane N.M.; Nicolete, RobertoAmerican tegumentary leishmaniasis (ATL) is considered a neglected disease, for which an e ff ective vaccine or an e ffi cient diagnosis is not yet available and whose chemotherapeutic arsenal is threatened by the emergence of resistance by etiological agents such as Leishmania amazonensis . ATL is endemic in poor countries and has a high incidence in Brazil. Vaccines developed from native parasite fractions ha...
PLGA Microspheres as new strategy to improve the efficiency of venom immunotherapy
Trindade, R eginaldo Almeida da; Sant’Anna, Osvaldo Augusto Brazil Esteves; Rescia, Vanessa Cristina; Bruni, Fernanda MirianiBackground: Despite considerable knowledge of allergy and its physiopathology, the only treatment with long - lasting effects for bee venom (BV) allergic patients is venom immunotherapy (VIT). Its efficiency has been recognized worldwide for many years. Howe ver, some limitations still result in patient rejection and prevent its use, such as the long treatment period with a total of 30 - 80 injections administe...