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Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Th...
Gonçalves Neto,Geraldo S.; Costa,Romário P. da; Zanini,Camila L.; Aguiar,Anna Caroline C.; Souza,Juliana O. de; Souza,Guilherme E. deQualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of both fruits and stems showed promising in vitro antiplasmodi...
In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya...
Gonring-Salarini,Karla L.; Conti,Raphael; Andrade,Jean Paulo de; Borges,Bárbara Juliana P.; Aguiar,Anna Caroline C.; Souza,Juliana O. deA combined phytochemical, crystallographic and biological study of Worsleya procera roots was performed. Fifteen alkaloids were identified by gas chromatography mass spectrometry (GC-MS) and seven of them were isolated. The structures of the alkaloids were elucidated by spectroscopic methods, and a detailed crystallographic study of tazettine was carried out. The isolated alkaloids and the obtained extracts wer...
PERSPECTIVAS DA QUÍMICA MEDICINAL PARA O SÉCULO XXI: DESAFIOS E OPORTUNIDADES
Andrade,Carolina Horta; Kümmerle,Arthur E.; Guido,Rafael V. C.In the 21st century, medicinal chemists will face many challenges to improve the quality of life of populations. The challenges consist of emerging infectious (ex. bacterial, viral and parasite infections) and non-communicable diseases (ex. autoimmune, Alzheimer disease, Parkinson’s disease) that will require innovative technologies (ex. microfluidics, nanotechnology, biotechnology) to be fully understood and c...
A EVOLUÇÃO DA QUÍMICA MEDICINAL NO BRASIL: AVANÇOS NOS 40 ANOS DA SOCIEDADE BRA...
Amaral,Antonia Tavares do; Andrade,Carolina Horta; Kümmerle,Arthur E.; Guido,Rafael V. C.Medicinal Chemistry includes the invention, discovery, design, identification, and interpretation of the molecular mechanism of action of biologically active compounds. In addition to the discovery of bioactive molecules, Medicinal Chemistry investigates drug metabolism and the relationships between chemical structure and biological activity. The advances achieved in the 20th century have significantly contribu...
Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanoso...
Cornelio,Vivian E.; Maluf,Fernando V.; Fernandes,João B.; Silva,Maria Fátima G. F. da; Oliva,Glaucius; Guido,Rafael V. C.; Vieira,Paulo C.Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme involved in the Trypanosoma cruzi glycolytic pathway, parasite that causes Chagas' disease. There are only few drugs available to treat this disease, most of which present strong side effects. Natural products constitute a prime source for the discovery of new scaffolds potentially useful for the treatment of several diseases, including Chagas' di...
Doenças tropicais negligenciadas: uma nova era de desafios e oportunidades
Dias,Luiz C.; Dessoy,Marco A.; Guido,Rafael V. C.; Oliva,Glaucius; Andricopulo,Adriano D.In an article recently published in Química Nova, entitled "Chemistry Without Borders" ("Química Sem Fronteiras") [Pinto, A. C.; Zucco, C.; Galembeck, F.; Andrade, J. B.; Vieira, P. C. Quim. Nova 2012, 35, 2092], the authors highlighted the important aspects of science and technology with special emphasis on the field of Chemistry and its contributions toward a more prosperous Brazil of future. As a second step...
Planejamento de fármacos, biotecnologia e química medicinal: aplicações em doen...
Guido,Rafael V. C.; Andricopulo,Adriano D.; Oliva,GlauciusEstratégias modernas de planejamento de fármacos se fundamentam no conhecimento da fisiopatologia das doenças, no estudo de vias bioquímicas e na seleção de alvos moleculares. As ferramentas biotecnológicas modernas têm fornecido informações valiosas para a descoberta e o desenvolvimento de novos fármacos. A química medicinal possui papel central em vários processos que visam à identificação de substâncias bioa...
Structural insights into the molecular basis responsible for the effects of imm...
Guido,Rafael V. C.; Cardoso,Carmen L.; Moraes,Marcela C. de; Andricopulo,Adriano D.; Cass,Quezia B.; Oliva,GlauciusThe development of fast and reliable methods for the identification of new bioactive compounds is of utmost importance to boost the process of drug discovery and development. Immobilized enzyme reactors (IMERs), integrated with high performance liquid chromatography (HPLC), are attractive and versatile tools for screening collections consisting of natural products and synthetic small molecules. Standard kinetic...