6 documents found, page 1 of 1
Improving the identification of high-risk non-metastatic castration-resistant p...
Rosinha, A; Rabaça, C; Calais, F; Pinto, JM; Barreira, JV; Fernandes, R; Ramos, R; Fialho, AC; Palma dos Reis, JNon-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in prostate cancer care. nmCRPC patients with a high risk of progression to metastatic disease who are identified by a prostate-specific antigen doubling time (PSADT) ≤10 months are eligible for treatment with the novel androgen receptor inhibitors (ARIs), shown to delay disease progression and extend survival. H...
Personalized Medicine: Paradigm Shift in ALK Positive Non-Small Cell Lung Cance...
Barreira, JV; Leão Mendes, J; Parmanande, ABackground: Since the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the...
Personalized medicine: paradigm shift in ALK positive non-small cell lung cance...
Barreira, JV; Mendes, JL; Parmanande, ABackground: Since the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the...
Bladder Cancer New Biomarkers in Liquid Biopsies
Falcão, G; Barreira, JV; Parmanande, A; Carneiro, C; Campos Pinheiro, LBladder cancer is one of the most common neoplasia in men in the developed countries. Diagnosis and surveillance are made by bladder examination through cystoscopy making this one of the most expensive on cost/patient. After tumor removal, clinical staging is important for prognosis and treatment decision as non-muscle invasive (Ta and T1) and invasive (T2+) are treated in a completely different way. Today no n...
Full Recovery of a Stage IV Cancer Patient Facing COVID-19 Pandemic
Parmanande, A; Simão, D; Sardinha, M; Palma dos Reis, AF; Spencer, AS; Barreira, JV; Luz, RCoronavirus disease 2019 (COVID-19), first recognized in Wuhan, China, was recently declared a global pandemic by the World Health Organization (WHO). Advanced age and comorbid disease, well-known characteristics in the solid tumor population, have been reported as risk factors for severe disease and death. Cancer-related immunosuppression and its treatments also seem to play an active role in the prognosis, re...
Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
Barreira, JV; Valejo Coelho, M; Ribeiro, C; Semedo, MThe authors present the case of a woman in the seventh decade of life with medical history of: left nephrectomy for renal tuberculosis and non-Hodgkin's lymphoma treated with chemotherapy (QT) and radiotherapy. She presented with a 2-month history of non-tender, left inguinal lymph node enlargement. Positron Emission Tomography (PET)-CT -scanshowed hypermetabolic inguinal and retroperitoneal lymphadenopathies, ...