3 documents found, page 1 of 1
Novel Edaravone Derivatives as Neuroprotective Agents for the Treatment of ALS
Barreiro, Sandra; Cagide, Fernando; Borges, Fernanda; Remião, Fernando; Silva, RenataBackground: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease (ND) with limited treatment options [1]. Although with some drawbacks, Edaravone is one of the available drugs for ALS that targets oxidative stress (OS), a key factor in the pathophysiology of this disease [1]. Objective: This work aimed to evaluate the cytotoxic effects and neuroprotective potential of a new series of Edaravone der...
Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidan...
Chavarria, Daniel; Da Silva, Ophelie; Benfeito, Sofia; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; Remião, FernandoNeurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study aims to evaluate whether the π-system extension on the chemical scaffolds of AntiOXCIN2 and AntiOXCIN3 affects their bioactivity and safety profiles. After the syn...
Referral and communication between primary and secondary care
Barreiro, SandraObjectives: To describe some aspects of the articulation between primary and secondary care in a restricted population of general practitioners. Method: Observational, descriptive and cross-sectional study, with the participation of 24 general practitioners working in public medical centres in the region of Lisbon and Almada. The physicians registered their re f e rrals for 8 weeks, and the replies from seconda...