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The alpha-lipoic acid improves survival and prevents irinotecan-induced inflamm...
Costa, Daniely V. S.; Costa, Deiziane V. S.; Sousa, Caren N. S.; Silva, Angeline M. H. P.; Medeiros, Ingridy S.; Martins, Dainesy S.Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-mediated intestinal inflammation, diarrhea and dysmotility. Intestinal mucositis was induced by irinotecan injection (75 mg/kg, i.p., for 4 days) in Swiss mice. α-LA (50, 100 or...
Date: 2021
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Origin: Oasisbr