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Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmentin...

Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria T.; Almeida, Isabel F.; Quintas, Clara; Garrido, Jorge

Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...


Comparative studies on the photoreactivity, efficacy, and safety of depigmentin...

Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria T.; Almeida, Isabel F.; Quintas, Clara

Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...


Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmentin...

Mota, Sandra; Rosa, Gonçalo P.; Barreto, Maria Carmo; Garrido, Jorge; Sousa, Emília; Cruz, Maria Teresa; Almeida, Isabel F.; Quintas, Clara

Depigmenting products are increasingly used to counteract skin hyperpigmentation and related psychosocial issues. This study aimed to compare different depigmenting agents—4-butylresorcinol; bakuchiol; tranexamic acid; ascorbyl glucoside; α-arbutin; and ascorbic acid—for photoreactivity; tyrosinase inhibition; and safety. Photoreactivity was assessed using the Reactive Oxygen Species assay. In vitro tyrosinase ...


Biochemical study of attached macroalgae from the Madeira Archipelago and beach...

Nunes, Nuno; Valente, Sofia; Ferraz, Sónia; Barreto, Maria Carmo; Carvalho, Miguel Â. A. Pinheiro de

Fifteen attached macroalgae from the Madeira Archipelago, comprising three green, three red and nine brown algal species, as well as two beach-cast macroalgal samples, collected along the north shore of Gran Canaria, were assessed for their biochemical properties. The anal ysis included the determination of total minerals, total carbohydrates, protein, lipids, chlorophyll a, total carote noids, total phenolic c...


Pharmacological and cosmeceutical potential of Seaweed Beach-Casts of Macaronesia

Zárate, Rafael; Portillo, Eduardo; Teixidó, Sílvia; Carvalho, Miguel A. A. Pinheiro de; Nunes, Nuno; Ferraz, Sónia; Seca, Ana M. L.; Rosa, Gonçalo P.

Seaweed beach-casts are a seasonal phenomenon that regularly deposits tons of algae biomass on beaches, which are usually disposed of in landfills. The present work aimed to contribute to the valorization of this biomass by studying bioactivities that reveal its potential in the pharmaceutical and/or cosmeceutical industries. Methanol and ethanol extracts and fractions from 15 beach-casts biomass were tested fo...


Fatty acid composition, TLC screening, ATR-FTIR analysis, anti-cholinesterase a...

Nunes, N.; Rosa, G. P.; Ferraz, S.; Barreto, Maria Carmo; Carvalho, M. A. A. Pinheiro de

Three macroalgae collected at Madeira Island were included in this study to determine their potential for drug, nutraceutical, food, or supplement application. Fatty acid content was higher in Zonaria tournefortii (12.32 mg g−1 dw) with 16.58% of PUFAs, eicosapentaenoic acid (C20:5ω3), and arachidonic acid (20:4ω6) having concentrations of 2.59 and 1.17%, respectively. The anti-thrombogenic and anti-atherogenic...


Validation of a spectrophotometric methodology for a rapid iodine analysis in a...

Nunes, N.; Valente, S.; Ferraz, S.; Barreto, Maria Carmo; Carvalho, M.A.A. Pinheiro de

Iodine plays an important role in human metabolism and its deficiency is particularly harmful in pregnancy and childhood. It remains a major public health concern in many countries, especially in Portugal. The main purpose of this work was to develop a validated spectrophotometric analysis for a fast and reliable iodine quantification in algal samples. Absorbance was determined at 410 nm demonstrating a good li...


Evaluation of fucoxanthin contents in seaweed biomass by vortex-assisted solid-...

Nunes, N.; Leça, João M.; Pereira, Ana C.; Pereira, Vanda; Ferraz, S.; Barreto, Maria Carmo; Marques, José C.; Carvalho, M.A.A. Pinheiro de

Fucoxanthin is considered an important marine bioactive compound with biological properties with promising effects, namely on health. A simple and efficient analytical methodology is proposed for its quantification in seaweed biomass by using vortex-assisted solid-liquid microextraction (VASLME) followed by reversed phase high-performance liquid chromatography (RP-HPLC) photodiode array detection (PDA) analysis...


Constructing ethanol-derived bioactive extracts using the brown seaweed Zonaria...

Nunes, N.; Valente, S.; Ferraz, S.; Barreto, Maria Carmo; Carvalho, M.A.A. Pinheiro de

Understanding the biochemical and antioxidant composition and capacity of a target biomass is the first step to its selectivity as functional food which can enhance the ability to promote health by reducing the risk of chronic diseases. The main purpose of this work was to employ response surface methodology (RSM) to determine the effect of the independent variables, % of ethanol (50–96%), time of sonication (0...


Nutraceutical potential of Asparagopsis taxiformis (Delile) Trevisan extracts a...

Nunes, N.; Valente, S.; Ferraz, S.; Barreto, Maria Carmo; Carvalho, M. A. A. Pinheiro de

The main goal of the present work was to determine the nutraceutical potential of Asparagopsis taxiformis D. extracts from Madeira Archipelago south coast. Extraction methodologies consisted either/or in 72 hours stirring, at room temperature (M1), or 6 cycles of Soxhlet extraction (M2), both with re-extraction. Solvents used were distilled water, ethanol, methanol and ethyl acetate. M1 allowed to obtain the hi...


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