2 documents found, page 1 of 1
Multi-tissue transcriptomic-informed in silico investigation of drugs for the t...
Sierra, B; Magalhães, AC; Soares, D; Cavadas, B; Perez, AB; Alvarez, M; Aguirre, E; Bracho, C; Pereira, L; Guzman, MGTranscriptomics, proteomics and pathogen-host interactomics data are being explored for the in silico–informed selection of drugs, prior to their functional evaluation. The effectiveness of this kind of strategy has been put to the test in the current COVID-19 pandemic, and it has been paying off, leading to a few drugs being rapidly repurposed as treatment against SARS-CoV-2 infection. Several neglected tropic...
OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against d...
Sierra, B; Triska, P; Soares, P; Garcia, G; Perez, AB; Aguirre, E; Oliveira, M; Cavadas, B; Regnault, B; Alvarez, M; Ruiz, D; Samuels, DCEthnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective against the haemorrhagic phenotype. Global ancestry analysis based on high-throughput genotyping in admixed populations can be used to test this hypothesis, while admixture ma...