2 documents found, page 1 of 1
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Andrade, EB; Magalhães, A; Puga, A; Costa, M; Bravo, J; Portugal, CC; Ribeiro, A; Correia-Neves, M; Faustino, A; Firon, A; Trieu-Cuot, P; Summavielle, TGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against G...
Alves, Joana; Madureira, P; Baltazar, MT; Barros, L; Oliveira, L; Ricardo Jorge Dinis Oliveira; Andrade, EB; Ribeiro, A; Vieira, LM; Trieu Cuot, PGroup B Streptococcus (GBS), a commensal organism, can turn into a life-threatening pathogen in neonates and elderly, or in adults with severe underlying diseases such as diabetes. We developed a vaccine targeting the GBS glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme detected at the bacterial surface, which was proven to be effective in a neonatal mouse model of infection. Since this bac...