5 documents found, page 1 of 1
Localized cancer photodynamic therapy approach based on core–shell electrospun ...
Costa, Sofia M.; Lourenço, Leandro M.O.; Calhelha, Ricardo C.; Calejo, Isabel; Barrias, Cristina C.; Fangueiro, Raul; Ferreira, Diana P.Photodynamic therapy (PDT) has been considered a promising treatment for several types of cancer, including cervical cancer. Localized drug delivery systems (DDSs) based on nanofibers produced by electrospinning have emerged as a powerful platform to carry and deliver photosensitizers (PSs) onto or adjacent to the tumor site, thereby promoting higher therapeutic efficacy and reducing the side effects to healthy...
Localized cancer photodynamic therapy approach based on core–shell electrospun ...
Costa, Sofia Maria Soares; Lourenço, Leandro M. O.; Calhelha, Ricardo C.; Calejo, Isabel; Barrias, Cristina C.; Fangueiro, Raúl; Ferreira, Diana P.Photodynamic therapy (PDT) has been considered a promising treatment for several types of cancer, including cervical cancer. Localized drug delivery systems (DDSs) based on nanofibers produced by electrospinning have emerged as a powerful platform to carry and deliver photosensitizers (PSs) onto or adjacent to the tumor site, thereby promoting higher therapeutic efficacy and reducing the side effects to healthy...
Geometrically controlled liquefied capsules for modular tissue engineering stra...
Nadine, Sara; Patrício, Sónia G.; Barrias, Cristina C.; Choi, Insung S.; Matsusaki, Michiya; Correia, Clara R.; Mano, João F.A plethora of bioinspired cell-laden hydrogels are being explored as building blocks that once assembled are able to create complex and highly hierarchical structures recapitulating the heterogeneity of living tissues. Yet, the resulting 3D bioengineered systems still present key limitations, mainly related with limited diffusion of essential molecules for cell survival, which dictates the failure of most strat...
A single-component hydrogel bioink for bioprinting of bioengineered 3D construc...
Pereira, Rúben; Sousa, Aureliana; Barrias, Cristina C.; Bártolo, Paulo J.; Granja, Pedro L.Bioprinting is attractive to create cellularized constructs for skin repair. However, the vast majority of bioinks present limitations in the printing of chemically defined 3D constructs with controllable biophysical and biochemical properties. To address this challenge, a single-component hydrogel bioink with a controlled density of cell-adhesive ligands, tuneable mechanical properties and adjustable rheologic...
Cell-instructive pectin hydrogels crosslinked via thiol-norbornene photo-click ...
Pereira, Rúben; Barrias, Cristina C.; Bártolo, Paulo J.; Granja, Pedro L.Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix compo nents. This paper describes the synthesis and photocrosslinking of cell-instructive pectin hydrogels using cell-degradable peptide crosslinkers and integrin-specific adhesive ligands. Protease-degradable ...