19 documents found, page 1 of 2
HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association ...
Cardoso, Elsa M.; Gomes, Vânia Lourenço; Esgalhado, André J.; Ferreira, Débora Reste; Oliveira, Nádia; Amaral, Ana Saraiva; Martinho, AntónioMHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/predementia (NpD, n = 28), or with dementia (D, n = 28) w...
CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function
Esgalhado, AJ; Reste-Ferreira, Débora; Albino, Stephanie; Sousa, Adriana; Amaral, Ana Paula; Martinho, António; Oliveira, Isabel Tomás; Verde, IgnacioThere is increasing evidence that in humans the adaptive immunological system can influence cognitive functions of the brain. We have undertaken a comprehensive immunological analysis of lymphocyte and monocyte populations as well as of HLA molecules expression in a cohort of elderly volunteers (age range, 64-101) differing in their cognitive status. Hereby, we report on the identification of a novel signature ...
TGF-β1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Path...
Serralheiro, Pedro M. Azevedo; Soares, Andreia M.; Almeida, Carlos M. Costa; Verde, IgnacioChronic venous insufficiency and varicose veins occur commonly in affluent countries and are a socioeconomic burden. However, there remains a relative lack of knowledge about venous pathophysiology. Various theories have been suggested, yet the molecular sequence of events is poorly understood. Transforming growth factor-beta one (TGF-β1) is a highly complex polypeptide with multifunctional properties that has ...
Variability of MMP/TIMP and TGF-β1 Receptors throughout the Clinical Progressio...
Serralheiro, Pedro; Novais, António; Cairrão, Elisa; Maia, Cláudio; Almeida, Carlos M. Costa; Verde, IgnacioChronic venous disease (CVeD) is a prevalent condition with a significant socioeconomic burden, yet the pathophysiology is only just beginning to be understood. Previous studies concerning the dysregulation of matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of metalloproteinases (TIMPs)) within the varicose vein wall are inconsistent and disregard clinical progression. Moreover, it is h...
Effects of Di-(2-ethylhexyl) phthalate on vascular smooth muscle cells
Mariana, Melissa; Cairrão, Elisa; Verde, IgnacioEvery year million tons of plastic are produced around the world and humans are increasingly exposed to them. This constant exposure has raised some concerns against human health and substances leaching from plastics, such as phthalates. These compounds, used to give flexibility to polyvinyl chloride (PVC), are endocrine-disrupting compounds because they have the ability to interfere with hormone pathways. Phth...
Efeito do Bisfenol A na regulação da contração da artéria umbilical humana
Oliveira, Nádia; Feiteiro, Joana; Cairrão, Elisa; Verde, IgnacioO bisfenol A (BPA) é um composto orgânico largamente utilizado na indústria de plásticos, tintas / vernizes, materiais de conexão e materiais de enchimento. É também utilizado como retardador de chamas, fluidos para travões e papéis térmicos. O BPA é maioritariamente utilizado na produção de plásticos (~ 3,8 milhões de toneladas por ano), incluindo embalagens de alimentos, brinquedos, monómeros odontológicos e ...
Efeitos do TBT em células vasculares: estado da arte e trabalho futuro
Barros, Ana R.; Feiteiro, Joana; Cairrão, Elisa; Verde, Ignacio; Barroso, Carlos M.; Sousa, Ana C. A.O tributilestanho (TBT) é um contaminante ambiental com uma distribuição à escala mundial, considerado como um dos mais potentes disruptores endócrinos, sendo também considerado como um composto obesogénico e imunotóxico. Os seres humanos estão expostos a este e outros compostos orgânicos de estanhos de várias formas, sendo a ingestão de alimentos, especialmente peixe e marisco, e de água da rede pública, vias ...
5α-Dihydrotestosterone regulates the expression of L-type calcium channels and ...
Marques, Ricardo; Peres, Carina; Vaz, Cátia; Gomes, Inês; Figueira, Marília I; Cairrão, Elisa; Verde, Ignacio; Baptista, Cláudio; Socorro, SílviaAndrogens have been associated with the development of normal breast, and their role in mammary gland carcinogenesis has also been described. Several studies reported that androgens inhibit breast cancer cell growth, whereas others linked their action with the modulation of calcium (Ca(2+)) pumps, Ca(2+) channels and Ca(2+)-binding proteins. Also, it is known that deregulated Ca(2+) homeostasis has been implica...
Long- and short-term effects of androgens in human umbilical artery smooth muscle
Saldanha, Paulo; Cairrão, Elisa; Baptista, Cláudio; Verde, IgnacioThe aim of the present study was to determine the effects of androgens in the regulation of human umbilical artery (HUA) contractility. The short-term effects of testosterone on the tone of the HUA were investigated, as were the long-term effects of dihydrotestosterone (DHT) on the expression of some proteins involved in the contractile process. Endothelium-denuded HUA were treated for 24 h with DHT (2 μmol/L) ...
Polyazamacrocycles as potential antitumor agents for human prostate cancer cells
Cruz, Carla; Cairrão, Elisa; Lourenço, Olga; Almeida, Paulo; Verde, Ignacio; Queiroz, JoãoPolyazamacrocycles are currently being studied and used in a variety of applications beyond their traditional place in supramolecular and co-ordination chemistry. This study suggests additional applications of these compounds with particular emphasis on their use as antiproliferative agents that could be potentially used to treat cancer. Four polyazamacrocycles were tested in human prostate cancer LNCaP and pro...