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Quality by Design Approach for the Development of Liposome Carrying Ghrelin for...

Barros, Cecília de; Aranha, Norberto; Severino, Patrícia; Souto, Eliana B.; Zielińska, Aleksandra; Lopes, André; Rios, Alessandra; Batain, Fernando

The therapeutic use of peptides has increasingly recognized in the development of new therapies. However, the susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect peptides against biodegradation and improve the accessibility to brain targets. The aim was to develop a liposomal formulation as ghrelin carrier. The quality by design (QbD) ...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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