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In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttle...

Pereira, Patrícia; Neto, Ana S.; Rodrigues, Ana Sofia; Barros, Inês; Miranda, Catarina O.; Santos, João Ramalho; Almeida, Luís Pereira de

This study investigates the osteogenic differentiation of umbilical-cord-derived human mesenchymal stromal cells (hUC-MSCs) on biphasic calcium phosphate (BCP) scaffolds derived from cuttlefish bone doped with metal ions and coated with polymers. First, the in vitro cytocompatibility of the undoped and ion-doped (Sr2+, Mg2+ and/or Zn2+) BCP scaffolds was evaluated for 72 h using Live/Dead staining and viability...


A autonomia como avanço para o futuro

Barros, Inês

A família desempenha um papel fundamental na vida das crianças e dos jovens. Porém, quando este não consegue cumprir com as necessidades das crianças e jovens, o Estado tem que intervir para assegurar as necessidades e o desenvolvimento das crianças e dos jovens. As casas de acolhimento têm que proporcionar as condições necessárias para que as crianças e jovens tenham as suas necessidades asseguradas, de modo q...


TOTAL THORACOSCOPIC THORACIC LYMPHADENECTOMY IN THE TREATMENT OF ESOPHAGEAL CANCER

Barros, Inês; Bártolo, Joana; Romano, Joana; Ramos, Paulo; Monteiro, Cecília; Casaca, Rui; Abecasis, Nuno

INTRODUCTION: In esophageal cancer, surgical resection and its corresponding lymphadenectomy remains the only therapeutic strategy that offers a possibility of cure. Despite the fact that a minimally invasive approach allows for an adequate lymphadenectomy with less associated morbidity, its high technical complexity means that many centers still do not perform it routinely. OBJECTIVE: Systematization...

Date: 2022   |   Origin: Revista Portuguesa de Cirurgia

Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multi...

Neto, Ana S.; Pereira, Patrícia; Fonseca, Ana C.; Dias, Carla; Almeida, Mariana C.; Barros, Inês; Miranda, Catarina O.; Almeida, Luís P. de

The present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers—poly("-caprolactone) (PCL) or poly(ester urea) (PEU)—loaded with an antibiotic drug, Rifampicin (RFP). The amounts of RFP incorporated into the PCL and PEU-coated scaffolds were 0.55 0.04 and 0.45 0.02 wt%, respectively. The in vitro drug release profiles in phosphate buffered salin...


Intervenções de enfermagem promotoras da adaptação da criança/jovem/família à h...

Barros, Inês; Lourenço, Margarida; Nunes, Elisabete; Charepe, Zaida

Objetivo: Identificar o processo de adaptação da criança e família à hospitalização e mapear as intervenções de enfermagem promotoras da adaptação à hospitalização da criança/jovem/família. Método: Elaboração de uma Scoping Review com base no Joanna Briggs Institute (2014). Critérios de inclusão - População: Criança, Jovem (0-18 anos); Conceito: Intervenções promotoras da adaptação e Contexto: Hospitalização. O...


ROBOT-ASSISTED LEFT HEPATECTOMY – CAUDAL APPROACH

Barros, Inês; Silva, Sílvia; Carrelha, Sofia; Santos Coelho, João; Pinto Marques, Hugo

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Date: 2021   |   Origin: Revista Portuguesa de Cirurgia

The Importance of sleep fragmentation on the hemodynamic dipping in obstructive...

Staats, Richard; Barros, Inês; Fernandes, Dina; Grencho, Dina; Reis, Cátia; Matos, Filipa; Valença, João; Marôco, João Paulo

Obstructive sleep apnea (OSA) has been associated with non-dipping blood pressure (BP). The precise mechanism is still under investigation, but repetitive oxygen desaturation and arousal induced sleep fragmentation are considered the main contributors.


Mesenchymal Stromal Cells' Therapy for Polyglutamine Disorders: Where Do We Sta...

Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Ramos, António David Rufino; Almeida, Luís P. de; Miranda, Catarina O.

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation encodes extended glutamine (Q) tract in the disease protein, resulting in the alteration of its conformation/physiological role and in the formation of toxic fragments/aggregates of the protein. This group of heterogeneous disorders shares common...


The importance of sleep fragmentation on the hemodynamic dipping in obstructive...

Staats, Richard; Barros, Inês; Fernandes, Dina; Grencho, Dina; Reis, Cátia; Matos, Filipa; Rodrigues, João Valença; Marôco, João

Introduction: Obstructive sleep apnea (OSA) has been associated with non-dipping blood pressure (BP). The precise mechanism is still under investigation, but repetitive oxygen desaturation and arousal induced sleep fragmentation are considered the main contributors. Methods: We analyzed beat-to-beat measurements of hemodynamic parameters (HPs) during a 25-min period of wake–sleep transition. Differences in the ...


Mesenchymal stromal cells’ therapy for polyglutamine disorders: where do we sta...

Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Rufino-Ramos, David; Pereira de Almeida, Luís; Miranda, Catarina O.

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation encodes extended glutamine (Q) tract in the disease protein, resulting in the alteration of its conformation/physiological role and in the formation of toxic fragments/aggregates of the protein. This group of heterogeneous disorders shares common...


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