This study investigates the osteogenic differentiation of umbilical-cord-derived human mesenchymal stromal cells (hUC-MSCs) on biphasic calcium phosphate (BCP) scaffolds derived from cuttlefish bone doped with metal ions and coated with polymers. First, the in vitro cytocompatibility of the undoped and ion-doped (Sr2+, Mg2+ and/or Zn2+) BCP scaffolds was evaluated for 72 h using Live/Dead staining and viability...
A família desempenha um papel fundamental na vida das crianças e dos jovens. Porém, quando este não consegue cumprir com as necessidades das crianças e jovens, o Estado tem que intervir para assegurar as necessidades e o desenvolvimento das crianças e dos jovens. As casas de acolhimento têm que proporcionar as condições necessárias para que as crianças e jovens tenham as suas necessidades asseguradas, de modo q...
INTRODUCTION: In esophageal cancer, surgical resection and its corresponding lymphadenectomy remains the only therapeutic strategy that offers a possibility of cure. Despite the fact that a minimally invasive approach allows for an adequate lymphadenectomy with less associated morbidity, its high technical complexity means that many centers still do not perform it routinely. OBJECTIVE: Systematization...
The present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers—poly("-caprolactone) (PCL) or poly(ester urea) (PEU)—loaded with an antibiotic drug, Rifampicin (RFP). The amounts of RFP incorporated into the PCL and PEU-coated scaffolds were 0.55 0.04 and 0.45 0.02 wt%, respectively. The in vitro drug release profiles in phosphate buffered salin...
Objetivo: Identificar o processo de adaptação da criança e família à hospitalização e mapear as intervenções de enfermagem promotoras da adaptação à hospitalização da criança/jovem/família. Método: Elaboração de uma Scoping Review com base no Joanna Briggs Institute (2014). Critérios de inclusão - População: Criança, Jovem (0-18 anos); Conceito: Intervenções promotoras da adaptação e Contexto: Hospitalização. O...
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Obstructive sleep apnea (OSA) has been associated with non-dipping blood pressure (BP). The precise mechanism is still under investigation, but repetitive oxygen desaturation and arousal induced sleep fragmentation are considered the main contributors.
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation encodes extended glutamine (Q) tract in the disease protein, resulting in the alteration of its conformation/physiological role and in the formation of toxic fragments/aggregates of the protein. This group of heterogeneous disorders shares common...
Introduction: Obstructive sleep apnea (OSA) has been associated with non-dipping blood pressure (BP). The precise mechanism is still under investigation, but repetitive oxygen desaturation and arousal induced sleep fragmentation are considered the main contributors. Methods: We analyzed beat-to-beat measurements of hemodynamic parameters (HPs) during a 25-min period of wake–sleep transition. Differences in the ...
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation encodes extended glutamine (Q) tract in the disease protein, resulting in the alteration of its conformation/physiological role and in the formation of toxic fragments/aggregates of the protein. This group of heterogeneous disorders shares common...