40 documents found, page 1 of 4
Dual-loaded chitosan-based nanoparticles: a novel approach for treating polymic...
Zegre, Miguel; Barros, J.; David, A. B.; Fialho, L.; Ferraz, M. P.; Monteiro, F. J.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.Developing innovative approaches to target osteomyelitis caused by polymicrobial infections remains a significant therapeutic challenge. In this study, monodispersed chitosan nanoparticles co-loaded with antibacterial (minocycline) and antifungal (voriconazole) agents were successfully prepared. Minocycline presented higher encapsulation efficiency as compared to voriconazole. Thermostability analysis suggested...
Poly(D,L-lactic acid) scaffolds as an innovative approach to the treatment of m...
Zegre, Miguel; Barros, J.; Ribeiro, I. A.; Santos, C.; Aranha Caetano, Liliana; Gonçalves, L.; Monteiro, F.; Ferraz, M.; Bettencourt, A.Introduction: The treatment of bacterial joint and bone infections in patients after multiple revision arthroplasties is very challenging. An expanding number of studies report the co-isolation of fungal and bacterial species (such as Candida albicans and Staphylococcus aureus) from polymicrobial biofilm associated with infections related to bone infections. Current investigations establish that local-specific ...
Poly(D,L-lactic acid) scaffolds as an innovative approach to the treatment of m...
Zegre, Miguel; Barros, J.; Ribeiro, I. A.; Santos, C.; Aranha Caetano, Liliana; Gonçalves, L.; Monteiro, F.; Ferraz, M.; Bettencourt, A.Problem - Bone infections associated with polymicrobial biofilm formation; mixed bacterial-fungal biofilm infection; Staphylococcus aureus and Candida albicans most described microbials. Strategy - Local drug delivery scaffolds; development of poly-DL-lactic acid (PDLLA) scaffolds; co-delivery of antibacterial and antifungal drugs; minocycline and voriconazole as model drugs.
Antibacterial and antioxidant potential of aqueous extracts of bio-residues fro...
Sousa, A. S.; Marçal, S.; Costa, C.; Ferreira, I.; Barros, J.; Nunes, J.; Freitas, A. C.; Morais, A. M. M. B.; Pintado, M.The production of fresh mushrooms results in a large quantity of bio-residues, which may account for more than 20% of a crop volume and contributes to production costs and environmental impact, if not used. These products consist mainly of stalks, mushrooms of irregular dimensions and shape and basal material. Thus, the main objective of MicoBioExtract project is the valorisation of these bio-residues and the d...
Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery...
Zegre, Miguel; Barros, J.; Ribeiro, I. A.; Santos, C; Caetano, Liliana Aranha; Gonçalves, L.; Monteiro, F. J.; Ferraz, M. P.; Bettencourt, A.New strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds pr...
Co-delivery of antimicrobials based on poly(D,L-lactic acid) 3D-scaffolds
Zegre, Miguel; Falcão, M.; Ribeiro, I. A.; Santos, C.; Barros, J.; Monteiro, F. J.; Ferraz, M. P.; Caetano, Liliana Aranha; Gonçalves, L.Bone infection treatment is a clinical challenge, often complicated by simultaneous polymicrobial infections. A growing number of studies address the co-isolation of fungal and bacterial species, such as Candida albicans and Staphylococcus aureus, from polymicrobial biofilm associated with osteomyelitis. Recent publications demonstrate that scaffolds with local drug delivery ability, display high antimicrobial ...
Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery...
Zegre, M.; Barros, J.; Ribeiro, Isabel A. C.; Santos, C; Caetano, L. A.; Gonçalves, Lídia; Monteiro, F. J.; Ferraz, M. P.; Bettencourt, Ana
Bacteriophage Phi 6 as Surrogate and Human-Harmless Viruses to Study Anti-SARS-...
Ferraz, MP; Monteiro, F.J.; Barros, J.
Encapsulated bacteriophages in alginate-nanohydroxyapatite hydrogel as a novel ...
Barros, J.; Melo, Luís Daniel Rodrigues; Silva, R. A.; Ferraz, M. P.; Azeredo, Joana; Pinheiro, V.; Colaço, B.; Fernandes, M. H.; Gomes, P. S.An innovative delivery system based on bacteriophages-loaded alginate-nanohydroxyapatite hydrogel was developed as a multifunctional approach for local tissue regeneration and infection prevention and control. Bacteriophages were efficiently encapsulated, without jeopardizing phage viability and functionality, nor affecting hydrogel morphology and chemical composition. Bacteriophage delivery occurred by swellin...
Minerais pesados de rochas metapsamíticas de Caminha (Norte de Portugal)
Barros, J.; Gomes, C. LealNas proximidades de Caminha, Noroeste de Portugal, afloram © sobretudo rochas cristalinas de natureza granítica e metavulcanossedimentar. Contudo, na localidade próxima de Vilar de Mouros, observam-se litologias de carácter metassedimentar, detrítico, siliciclástico, correspondentes a unidades de idade Silúrica a Devónica delimitadas por cavalgamentos de direção, progressivamente variável, de NNE-SSW a NE-SW. O...