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loysia citrodora extract as a chemopreventive agent against HPV16-induced lesio...

Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I; Silva, Jessica; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, Carmen

Aim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...


The role of natural compounds in rat mammary cancer: the beneficial effects of ...

Azevedo, Tiago; Silva, J; Faustino-Rocha, Ana I; Valada, A; Anjos, L; Moura, T; Ferreira, T; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F

Breast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, includ- ing anticancer and anti-diabetic properties. This study aimed to assess the chemopreven- tive effects of S. chamaecyparissus aqueous ex- tract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were...


Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...

Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana I

nfections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...


antolina chamaecyparissus L.: a brief overview of its medicinal properties

Azevedo, T; Faustino-Rocha, Ana I; Barros, L; Finimundy, TC; Matos, M; Oliveira, PA

Santolina chamaecyparissus, commonly known as cotton-lavender, is a plant with recog- nized medicinal properties that has been traditionally used in several conditions, including the relief of premenstrual syndrome, and the treatment of infections and digestive disorders. Its extracts have been found to have a range of therapeutic effects and can be used in modern medicine, due to their analgesic, anticancer, a...


Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...

Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, F

Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer


Santolina chamaecyparissus L.: a brief overview of its medicinal properties.

Azevedo, T; Faustino-Rocha, Ana I; Barros, L; Finimundy, TC; Matos, M; Oliveira, PA

Santolina chamaecyparissus L.: a brief overview of its medicinal properties.


Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...

Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, F

Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer.


Patterns of Parental Reactions to Their Children’s Negative Emotions: A Cluster...

Pereira, AI; Santos, C; Barros, L; Roberto, MS; Rato, J; Prata, A; Marques, C

Parents' emotion socialization practices are an important source of influence in the development of children's emotional competencies This study examined parental reactions to child negative emotions in a clinical sample using a cluster analysis approach and explored the associations between clusters of parents' reactions and children's and parents' adjustment. The sample comprised 80 parents of Portuguese chil...


Ganoderma lucidum effects in an animal model of obesity

Castro-Ribeiro, Carla; Silva-Reis, Rita; Mendes-Gonçalves, Mariana; Ferreira, Rita; Taofiq, O; Barros, L; Martins, Tânia; Faustino-Rocha, Ana Isabel

Obesity is a pandemic disease, and its evolution can be influenced by regular consumption of natural bioactive compounds. Mushrooms, such as Ganoderma lucidum (GL), include a wide variety of biomolecules with potential anti-obesity effects. This work aimed to study the influence of GL in an animal model of obesity. Forty-eight male mice (C57BL/6J) were divided into 5 groups: Group (G)-1-Western Control Diet; G-...


Castanea sativa mill. flowers as potential chemopreventive agent against rat pr...

Nascimento-Gonçalves, Elisabete; Silva, M; Seixas, Fernanda; Fardilha, Margarida; Ferreira, Rita; Neuparth, Maria João; Faustino-Rocha, Ana Isabel

Introduction: Prostate cancer is one of the most common cancer among men, having a huge impact in their health [1]. This work aimed to evaluate the influence of a decoction extract obtained from C. sativa flowers (CF) on chemically and hormonally induced rat prostate cancer animal model. Material & Methods: All the animal experiments were approved by the Institutional Animals Ethics Committee and by Portuguese ...


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