6 documents found, page 1 of 1
Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of ado...
Blanco Dominguez, Rafael; Barros, Leandro; Carreira, Mariana; van der Ploeg, Manon; Condeço, Carolina; Marsères, Gabriel; Ferreira, CristinaColorectal cancer (CRC) remains a challenge for current immunotherapies. Vδ1+ γδ T cells offer a promising alternative because of their HLA-I-independent cytotoxicity and natural tissue tropism. We developed Delta One T (DOT) cells, a Vδ1+ γδ T cell-based adoptive cell therapy clinically explored for hematological malignancies but not yet for solid tumors. Here we demonstrate the capacity of DOT cells to target...
CD155/PVR determines acute myeloid leukemia targeting by Delta One T cells
Mensurado, Sofia; Condeço, Carolina; Sánchez-Martínez, Diego; Shirley, Sara; Coelho, Rui; Tirado, Néstor; Vinyoles, Meritxell; Blanco Dominguez, RafaelRelapsed or refractory acute myeloid leukemia (AML) remains a major therapeutic challenge. We have recently developed a Vδ1+ γδ T cell-based product for adoptive immunotherapy, named Delta One T (DOT) cells, and demonstrated their cytolytic capacity to eliminate AML cell lines and primary blasts in vitro and in vivo. However, the molecular mechanisms responsible for the broad DOT-cell recognition of AML cells r...
CD8+ tissue-resident memory T-cell development depends on infection-matching re...
Barros, Leandro; Piontkivska, Daryna; Figueiredo-Campos, Patrícia; Fanczal, Júlia; Ribeiro, Sofia Pereira; Baptista, Marta; Ariotti, SilviaImmunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, howe...
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
Ferreira, Cristina; Barros, Leandro; Baptista, Marta; Blankenhaus, Birte; Barros, André; Figueiredo-Campos, Patricia; Konjar, Spela; Lainé, AlexandraTissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the signals that direct development of TRM cells are incompletely understood. Here we show that type 1 regulatory T (Treg) cells, which express the transcription f...
Desastres naturais de origem hidro-geomorfológica no Baixo Mondego no período 1...
Tavares, Alexandre O.; Barros, Leandro; Santos, Pedro P.; Zêzere, Joel L.Apresenta-se uma base de dados de desastres naturais de origem hidro-geomorfológica reportados na imprensa escrita local, para a região do Baixo Mondego, no período 1961-2010. Os resultados salientam espacialmente a relevância das inundações em espaço urbano e das cheias progressivas em espaços de interface urbano/rural, assim como os movimentos de massa associados a infraestruturas viárias. A distribuição temp...
Desastres naturais de origem hidro-geomorfológica no Baixo Mondego no período 1...
Tavares, Alexandre O.; Barros, Leandro; Santos, Pedro Pinto; Zêzere, JoséApresenta-se uma base de dados de desastres naturais de origem hidro-geomorfológica reportados na imprensa escrita local, para a região do Baixo Mondego, no período 1961-2010. Os resultados salientam espacialmente a relevância das inundações em espaço urbano e das cheias progressivas em espaços de interface urbano/rural, assim como os movimentos de massa associados a infraestruturas viárias. A distribuição temp...