In liver transplantation, ischemia/reperfusion may cause serious injury to the graft. The aim of this study was to evaluate the effects of preconditioning with L-alanyl-glutamine in graft protection in patients undergoing liver transplantation. 33 patients undergoing liver transplantation at the Walter Cantídio University Hospital (HUWC) of the Federal University of Ceará (UFC), from 05/22/13 to 12/11/2013 were...
The hepatic transplant is the standard treatment for terminal hepatic illness. With the refinement of the surgical technique, improvement of the effectiveness of the immunosuppressive drugs, the better knowledge of the reperfusion injury and the use of more physiological solutions of preservation, had a considerable increase of the survival of hepatic graft. The Collins’ preservation solution used since 1969 , ...
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Evidence suggests that the carcinogenic process guided by Helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as BCL-2, BAX, and MYC. However, the literature is conflicting regarding the expression frequency in the histological subtypes and did not consider cagA gene presence. To investigate the expression of these proteins considering the histological subtypes of gastric cance...
ackground: The association between Helicobacter pylori gene diversity and gastric cancer has been poorly reported, although it is one of the important ways to explain the gastric pathogenesis. The aim of this study was to investigate the frequency of cag E and vir B11 genes in H. pylori isolated from patients with gastric cancer and to analyze the histology profiles. Materials and methods: The presence of H. py...
Objective. Decreases in p27 KIP1 and C-MYC expression have been associated with Helicobacter pylori infection. Furthermore, C-MYC seems to be a transcriptional repressor of p27 KIP1 . Therefore, in a series of gastric adenocarcinomas we studied the association of p27 KIP1 expression with H. pylori genotype ( vac A, cag A, cag E and vir B11) and the involvement of C-MYC in this process. Material and methods. Exp...
AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistr...