2 documents found, page 1 of 1
Pyrimidine Derivatives: QSAR Studies of Larvicidal Activity against Aedes aegypti
Monte,Zenaide S.; Navarro,Daniela M. A. F.; Aguiar,Júlio C. R. O. F.; Nascimento,Jessica S.; Scotti,Marcus T.; Scotti,Luciana; Barros,Renata P. C.The present study investigated the activity of pyrimidine derivatives against Aedes aegypti. Two compounds, 3c and 3d showed excellent larvicide activity. Additionally, quantitative structure-activity relationship (QSAR) models were built using multiple-linear regression and partial least squares with descriptors generated from Dragon and VolSurf+ software, respectively. The best model is obtained with multiple...
Virtual Screening of Secondary Metabolites of the Family Velloziaceae J. Agardh...
Pinheiro,Anderson A. V.; Barros,Renata P. C.; Assis,Edileuza B. de; Maia,Mayara S.; Araújo,Diego I. A. F. de; Sales,Kaio A.; Scotti,LucianaThe objective of this work was to carry out a bibliographic survey of secondary metabolites isolated from the Velloziaceae family, creating a bank of compounds. After the bank was created, four prediction models for potentially active compounds against pathogenic microorganisms (Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Salmonella sp.) were obtained trying to identify which metabolites woul...