8 documents found, page 1 of 1

Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogram...

Advanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...

Metabolic regulation of antifungal immunity: from basic mechanisms to clinical ...

Aspergillus fumigatus é um fungo oportunista responsável por um largo espectro de doenças com manifestações clínicas, que podem ir desde a colonização a síndromes alérgicos, até formas invasivas de infeção. Até à data, não existem vacinas aprovadas para a aspergilose e os métodos usados para o diagnóstico desta doença não apresentam sensibilidade e especificidade adequadas, o que resulta em altas taxas de morbi...

Host genetic signatures of susceptibility to fungal disease

Our relative inability to predict the development of fungal disease and its clinical outcome raises fundamental questions about its actual pathogenesis. Several clinical risk factors are described to predispose to fungal disease, particularly in immunocompromised and severely ill patients. However, these alone do not entirely explain why, under comparable clinical conditions, only some patients develop infectio...

Role of deficits in pathogen recognition receptors in infection susceptibility

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Invasive aspergillosis (IA) is a severe infection that can occur in severely immunocompromised patients. Efficient immune recognition of Aspergillus is crucial to protect against infection, and previous studies suggested a role for NOD2 in this process. However, thorough investigation of the impact of NOD2 on susceptibility to aspergillosis is lacking. Common genetic variations in NOD2 has been associated with ...

Evaluation of Bronchoalveolar Lavage Fluid Cytokines as Biomarkers for Invasive...

Background: Invasive pulmonary aspergillosis (IPA) is an infection that primarily affects immunocompromised hosts, including hematological patients and stem-cell transplant recipients. The diagnosis of IPA remains challenging, making desirable the availability of new specific biomarkers. High-throughput methods now allow us to interrogate the immune system for multiple markers of inflammation with enhanced reso...

Translating the host-microbiota interaction into risk assessment of invasive as...

Invasive aspergillosis (IA) is an infection that affects primarily immunocompromised hosts, including hematological patients and stem-cell transplant recipients. Owing to an increasing incidence and despite available antifungal therapy, IA is a leading cause of mortality in these settings. This scenario is worsened by limitations in current diagnostic approaches and evolution of drug resistance in the fungus. T...

The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal d...

Filamentous fungi of the genus Aspergillus are responsible for several superficial and invasive infections and allergic syndromes. The risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and pathogen exposure. There is increasing evidence that the individual microbiome supervises the outcome of the host-fungus interaction by influencing me...