8 documents found, page 1 of 1
Germline cdh1 g212e missense variant: Combining clinical, in vitro and in vivo ...
Figueiredo, J; Mercadillo, F; Melo, S; Barroso, A; Gonçalves, M; Díaz-Tasende, J; Carneiro, P; Robles, L; Colina, F; Ibarrola, C; Perea, JE-cadherin, encoded by CDH1, is an essential molecule for epithelial homeostasis, whose loss or aberrant expression results in disturbed cell–cell adhesion, increased cell invasion and metas-tasis. Carriers of CDH1 germline mutations have a high risk of developing diffuse gastric cancer and lobular breast cancer, associated with the cancer syndrome Hereditary Diffuse Gastric Cancer (HDGC). The ubiquitous availa...
Real-world data from the Portuguese Nivolumab Expanded Access Program (EAP) in ...
Figueiredo, A; Almeida, M A; Almodovar, M T; Alves, P; Araújo, A; Araújo, D; Barata, F; Barradas, L; Barroso, A; Brito, U; Camacho, E; Canário, DOBJECTIVE: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. METHODS: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility crite...
BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases th...
Dionísio, MR; Vieira, AF; Carvalho, R; Conde, I; Oliveira, M; Gomes, M; Pinto, MT; Pereira, P; Pimentel, J; Souza, C; Marques, MMC; Silva, VDBrain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably arise by the seeding of cancer cells with stem features. Accordingly, we found that brain-tropic breast cancer cells show increased stem cell activity and ...
Corpo Estranho na Tiróide
Breda, M; Silva, D; Pereira, S; Miranda, D; Moreira, F; Guimarães, J; Marçal, N; Barroso, A; Dias, L
Abordagem de Adenocarcinoma do Seio Maxilar a Propósito de um Caso Clínico
Pereira, S; Miranda, D; Silva, D; Marçal, N; Barroso, A; Dias, L
Reacções cutâneas adversas aos inibidores do EGFR: receptor do factor de cresci...
Varela, P; Gonçalo, Margarida; Moura, C; Barroso, A
Reacções cutâneas adversas aos inibidores do EGFR: receptor do epidermal growth...
Moura, C; Gonçalo, Margarida; Barroso, A; Varela, P
Foreign bodies in the tracheobronchial tree. 12 years' experience.
Agostinho, M; Estevão, H M; Boavida, E; Pires, J; Pato, R; Isaac, J B; Coelho, A; Barroso, ADuring a period of twelve years--January 1983 to December 1994, 371 children suspected of foreign body inhalation were admitted in Hospital Pediatric of Coimbra. The diagnosis was confirmed in 200 of them (54%), and this group was analysed. The incidence has increased until 1989 and stabilized in the last 5 years with a median of 18 cases/year. Two third of the children were boys and 84% were under three years ...