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Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate fo...
Castro, JP; Fernando, R; Reeg, S; Meinl, W; Almeida, H; Grune, TAging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of proteostasis loss. In cells, during stress conditions, actin aggregates accumulate leading to impaired proliferation and reduced proteasomal activity, as observed in cellu...
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto