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Acute-on-Chronic Liver Failure: A Portuguese Single-Center Reference Review

Verdelho, M; Perdigoto, R; Machado, J; Mateus, É; Marcelino, P; Pereira, R; Fortuna, P; Bagulho, L; Bento, L; Ribeiro, F; Nolasco, F; Martins, A

Acute-on-chronic liver failure (ACLF) is a syndrome characterized by an acute deterioration of a patient with cirrhosis, frequently associated with multi-organ failure and a high short-term mortality rate. We present a retrospective study that aims to characterize the presentation, evolution, and outcome of patients diagnosed with ACLF at our center over the last 3 years, with a comparative analysis between the...




Preoperative Metabolic Status Is Associated with Different Evolution of Resting...

Brito-Costa, A; Pereira-da-Silva, L; Papoila, AL; Alves, M; Mateus, E; Nolasco, F; Barroso, E

Introduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver tran...


Liver transplantation for colorectal liver metastasis: Survival without recurre...

Toso, C; Pinto Marques, H; Andres, A; Castro e Sousa, F; Adam, R; Kalil, A; Clavien, PA; Furtado, E; Barroso, E; Bismuth, H


Mielinólise Centropôntica e Extrapôntica: Experiência de um Centro de Transplan...

Fernandes, MA; Miranda, S; Marcelino, P; Mega, I; Machado, J; Perdigoto, R; Barroso, E

Introdução: A mielinólise centropôntica e extrapôntica (MCPEP) é uma síndrome desmielinizante rara. A MCPEP é mais prevalente em receptores de transplante hepático tendo um prognóstico desfavorável associado. A correção rápida de hiponatremia e agentes imunossupressores, como os inibidores da calcineurina, foram identificados como causas possíveis para o desenvolvimento desta patologia. Métodos: Os autores desc...


Resection of Colorectal Liver Metastases After Second-Line Chemotherapy: Is It ...

Adam, R; Yi, B; Innominato, PF; Barroso, E; Laurent, C; Giuliante, F; Capussotti, L; Lapointe, R; Regimbeau, JM; Lopez-Ben, S; Isoniemi, H; Hubert, C

PURPOSE: Patient outcome after resection of colorectal liver metastases (CLM) following second-line preoperative chemotherapy (PCT) performed for insufficient response or toxicity of the first-line, is little known and has here been compared to the outcome following first-line. PATIENTS AND METHODS: From January 2005 to June 2013, 5624 and 791 consecutive patients of a prospective international cohort received ...


Tuberculosis in Liver Transplant Recipients: A Report of Eight Cases During a F...

Póvoas, D; Machado, J; Perdigoto, R; Morbey, A; Veloso, J; Glória, H; Mateus, E; Martins, A; Maltez, F; Barroso, E

Introduction: Tuberculosis incidence in Portugal ranged from 20 to 22 cases per 100 000 inhabitants between 2010 and 2014. Tuberculosis incidence in liver transplant recipients is not precisely known, but it is estimated to be higher than among the general population. Tuberculosis in liver transplant recipients is particularly challenging because of the atypical clinical presentation and side effects of the ant...


Outcomes of Parenchyma-Preserving Hepatectomy and Right Hepatectomy for Solitar...

Hosokawa, I; Allard, MA; Mirza, DF; Kaiser, G; Barroso, E; Lapointe, R; Laurent, C; Ferrero, A; Miyazaki, M; Adam, R

BACKGROUND: Occasionally, right hepatectomy, rather than parenchyma-preserving hepatectomy, has been performed for solitary small colorectal liver metastasis. The relative oncologic benefits of parenchyma-preserving hepatectomy and right hepatectomy are unclear. This study compared the outcomes of patients with solitary small colorectal liver metastasis in the right liver who underwent parenchyma-preserving hep...


Simultaneous Kidney-Pancreas Transplantation With an Original "Transverse Pancr...

Paulino, J; Martins, A; Vigia, E; Marcelino, P; Nobre, AM; Bicho, L; Filipe, E; Barroso, E

An innovative technique for pancreas transplantation is described. The main aspect consists of the horizontal positioning of the pancreas, which allows a better venous outflow, thus preventing thrombosis and graft loss. The program of pancreas transplantation in this national reference center for pancreatic and liver surgery was started in 2007; the initial results were considered poor, resulting in the loss of...


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