9 documents found, page 1 of 1
Efeito imunomodulador e sinaptogênico dos enantiômeros R- e S-cetamina no model...
Chaves Filho, Adriano José MaiaDepression is a disabling mental disorder associated with increased levels of pro-inflammatory cytokines and glial activation. Ketamine has emerged as a modifying agent in the psychopharmacology of depression, as it exerts effect in hours with high responsiveness. This drug, however, consists of a racemic mixture of the R- and S-ketamine enantiomers (R- and S-KET) that have different behavioral effects and mole...
Bothrops pauloensis snake venom-derived Asp-49 and Lys-49 phospholipases A2 med...
Marinho, Aline Diogo; Silveira, João Alison de Moraes; Chaves Filho, Adriano José Maia; Jorge, Antônio Rafael Coelho; Nogueira Júnior, Francisco AssisMade available in DSpace on 2021-06-25T11:09:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-30; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); University of Cambridge; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The envenomation caused by the Bothrops pauloensis snake leads to severe loca...
Leptin prevents lipopolysaccharide-induced depressive-like behaviors in mice: i...
Cordeiro, Rafaela Carneiro; Chaves Filho, Adriano José Maia; Medeiros, Camila Dantas; Queiroz, Ana Isabelle de Góis; Maes, Michael; Macedo, Danielle S.Depression is a chronic and recurrent disorder, associated with high morbidity and risk of suicide. Leptin was firstly described as an anti-obesity hormone, but several actions of leptin in CNS have been reported. In fact, leptin regulates dopaminergic neurotransmission in mesolimbic areas and has antidepressant-like properties in stress-based models. In the present study, we investigated, for the first time, p...
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression...
Macedo, Danielle; Chaves Filho, Adriano José Maia; Sousa, Caren Nádia Soares de; Quevedo, João; Barichello, Tatiana; Nobre Júnior, Hélio VitorianoObjectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this na...
α-Lipoic acid as adjunctive treatment for schizophrenia : an open-label trial
Sanders, Lia Lira Olivier; Menezes, Carlos Eduardo de Souza; Chaves Filho, Adriano José Maia; Viana, Glautemberg de Almeida; Fechine, Francisco VagnaldoPurpose/Background: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. Methods/Procedures: In this pilot investigation, we administered ALA (100 mg/d) for 4...
IDO chronic immune activation and tryptophan metabolic pathway : a potential pa...
Chaves Filho, Adriano José Maia; Lima, Camila Nayane Carvalho; Vasconcelos, Silvânia Maria Mendes; Lucena, David Freitas de; Maes, MichaelObesity and depression are among the most pressing health problems in the contemporary world. Obesity and depression share a bidirectional relationship, whereby each condition increases the risk of the other. By in- ference, shared pathways may underpin the comorbidity between obesity and depression. Activation of cell- mediated immunity (CMI) is a key factor in the pathophysiology of depression. CMI cytokines,...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...
N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent ...
Okamura, Adriana Mary Nunes Costa; Gomes, Patrícia Xavier L.; Oliveira, Gersilene V. de; Araújo, Fernanda Yvelize R. de; Tomaz, Viviane S.Kindling We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To ...
Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in m...
Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Chaves Filho, Adriano José Maia; Rios, Emiliano Ricardo VasconcelosThis study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of o...