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Non-Surgical Periodontal Treatment Impact on Subgingival Microbiome and Intra-O...

Izidoro, Catarina; Botelho, João; Machado, Vanessa; Reis, Ana Mafalda; Proença, Luís; Barroso, Helena; Alves, Ricardo; Mendes, José João

The purpose of this study was to characterize and compare subgingival microbiome before and after periodontal treatment to learn if any changes of the subgingival microbiome were reflected in intra-oral halitosis. We tested the hypothesis that intra-oral halitosis (Volatile sulfur compounds levels) correlates with corresponding subgingival bacterial levels before and after periodontal treatment. Twenty patients...


An HIV-1/HIV-2 Chimeric Envelope Glycoprotein Generates Binding and Neutralisin...

Taveira, Nuno; Figueiredo, Inês; Calado, Rita; Martin, Francisco; Bártolo, Inês; Marcelino, José Maria; Borrego, Pedro; Cardoso, Fernando M H

The development of immunogens that elicit broadly reactive neutralising antibodies (bNAbs) is the highest priority for an HIV vaccine. We have shown that a prime-boost vaccination strategy with vaccinia virus expressing the envelope glycoprotein gp120 of HIV-2 and a polypeptide comprising the envelope regions C2, V3 and C3 elicits bNAbs against HIV-2. We hypothesised that a chimeric envelope gp120 containing th...


An HIV-1/HIV-2 Chimeric Envelope Glycoprotein Generates Binding and Neutralisin...

Taveira, Nuno; Figueiredo, Inês; Calado, Rita; Martin, Francisco; Bártolo, Inês; Marcelino, José M.; Borrego, Pedro; Cardoso, Fernando M H

The development of immunogens that elicit broadly reactive neutralising antibodies (bNAbs) is the highest priority for an HIV vaccine. We have shown that a prime-boost vaccination strategy with vaccinia virus expressing the envelope glycoprotein gp120 of HIV-2 and a polypeptide comprising the envelope regions C2, V3 and C3 elicits bNAbs against HIV-2. We hypothesised that a chimeric envelope gp120 containing th...


Association of herpesvirus and periodontitis: a clinical and laboratorial case-...

Picolo, Marta; Nobre, Miguel de Araújo; Salvado, Francisco; Barroso, Helena

Objectives: A significant influence of the Herpesviridae family in the progression of periodontal disease has been suggested. The aim of this study was to investigate the potential association of four Herpesviruses (HSV-1, HSV-2, cytomegalovirus [CMV], and Epstein-Barr virus [EBV]) with periodontal disease using a qualitative test for evaluating the presence or absence of viral DNA in crevicular fluid samples o...


An HIV-1/HIV-2 chimeric envelope glycoprotein generates binding and neutralisin...

Taveira, Nuno; Figueiredo, Inês; Calado, Rita; Martin, Francisco; Bártolo, Inês; Marcelino, José M.; Borrego, Pedro; Cardoso, Fernando; Barroso, Helena

The development of immunogens that elicit broadly reactive neutralising antibodies (bNAbs) is the highest priority for an HIV vaccine. We have shown that a prime-boost vaccination strategy with vaccinia virus expressing the envelope glycoprotein gp120 of HIV-2 and a polypeptide comprising the envelope regions C2, V3 and C3 elicits bNAbs against HIV-2. We hypothesised that a chimeric envelope gp120 containing th...


The 5th International Congress of CiiEM : Reducing inequalities in Health and S...

Barroso, Helena; Castro, Cidália

The 5th International Congress of CiiEM (IC CiiEM) took place on 16–18 June 2021, as a multidisciplinary scientific online forum focused on Reducing Inequalities in Health and Society. The congress brought together experts from several fields to present their latest findings, experiences and proposals. It included topics such as Personalized Health Intervention, Infectious Diseases and Improving Global Health, ...




Massive testing Is important to control a SARS-CoV-2 outbreak

Guerreiro, Daniela; Costa, Ana Luísa; Nascimento, Teresa; Ribeiro, Ana Clara; Proença, Luís; Mendes, José João; Barroso, Helena

At the end of September 2020, an outbreak of SARS-CoV-2 occurred at a university student’s residence. A rapid response, with massive testing, using both RT-PCR and antigen rapid testing, helped to control the spread of the virus, showing the importance of tracking the infection. Testing for antibodies one month after the outbreak showed that the permanence of students with no infection in the same building was ...


Candida spp. colonization among intensive care unit patients : preliminary results

Nascimento, Teresa; Inácio, João; Ferreira, Isabel; Diaz, Priscila; Freitas, Paulo; Barroso, Helena

Candida spp. colonization is recognized as a major risk factor for invasive candidiasis. To assess patient colonization, upon admission and during their stay in intensive care units (ICU), a surveillance study has been conducted since January 2020, in the Lisbon area of Portugal. A total of 219 swab samples were obtained from 113 ICU patients. The yeast identification was conducted by microbiological convention...


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