5 documents found, page 1 of 1
Segurança humana
Seminário 'Segurança Humana : A Dimensão Securitária e o Apoio ao Desenvolvimento', Lisboa, Fevereiro 2023; Nunes, Isabel Ferreira; Seabra, Pedro
Genomic and epigenetic signatures associated with survival rate in oral squamou...
Ribeiro, Ilda Patrícia; Caramelo, Francisco; Esteves, Luísa; Oliveira, Camila; Marques, Francisco; Barroso, Leonor; Melo, Joana BarbosaPurpose: Although oral squamous cell carcinoma (OSCC) presents great mortality and morbidity worldwide, the mechanisms behind its clinical behavior remain unclear. Biomarkers are needed to forecast patients' survival and, among those patients undergoing curative therapy, which are more likely to develop tumor recurrence/metastasis. Demonstrating clinical relevance of these biomarkers could be crucial both for s...
Genetic and epigenetic characterization of the tumors in a patient with a tongu...
Ribeiro, Ilda Patrícia; Marques, Francisco; Barroso, Leonor; Miguéis, Jorge; Caramelo, Francisco; Santos, André; Julião, Maria J.; Melo, Joana B.Background: The choice of therapeutic modality for oral carcinoma in recurrent or second primary tumors remains controversial, as the treatment modalities available might be reduced by the treatment of the first tumor, and the overall survival is lower when compared with patients with a single or first tumor. Identifying biomarkers that predict the risk of relapse and the response to treatment is an emerging cl...
Genomic predictive model for recurrence and metastasis development in head and ...
Ribeiro, Ilda Patrícia; Caramelo, Francisco; Esteves, Luísa; Menoita, Joana; Marques, Francisco; Barroso, Leonor; Miguéis, Jorge; Melo, Joana BarbosaThe head and neck squamous cell carcinoma (HNSCC) population consists mainly of high-risk for recurrence and locally advanced stage patients. Increased knowledge of the HNSCC genomic profile can improve early diagnosis and treatment outcomes. The development of models to identify consistent genomic patterns that distinguish HNSCC patients that will recur and/or develop metastasis after treatment is of utmost im...
Early detection and personalized treatment in oral cancer: the impact of omics ...
Ribeiro, Ilda Patrícia; Barroso, Leonor; Marques, Francisco; Melo, Joana Barbosa; Carreira, Isabel MarquesBackground: Oral cancer is one of the most common malignant lesions of the head and neck. This cancer is an aggressive and lethal disease with no significant improvements in the overall survival in the last decades. Moreover, the incidence of oral HPV-positive tumors is rising, especially in young people. This oral neoplasm develops through numerous molecular imbalances that affect key genes and signaling pathw...