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Determination of Arylcyclohexylamines in Biological Specimens: Sensors and Samp...
Pelixo, Rodrigo; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoArylcyclohexylamine (ACH) compounds represent a predominant faction within new psychoactive substances. Due to their powerful dissociative effects, they are used in recreational contexts but also in situations of drug-facilitated sexual assault, and therefore, they are a constant target of analysis by forensic experts. In recent years, their consumption has been notably high, especially the use of ketamine, pre...
Determination of Antiepileptics in Biological Samples—A Review
Martinho, João; Simão, Ana Y.; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoEpilepsy remains a disease that affects many people around the world. With the development of new drugs to treat this condition, the importance of therapeutic drug monitoring continues to rise and remains a challenge for the medical community. This review article explores recent advances in the detection of antiepileptic drugs across various sample types commonly used for drug monitoring, with a focus on their ...
Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medica...
Pires, Bruno; Oliveira, Patrik; Simão, Ana Y.; Reis, João; Ramos, Sofia; Duarte, Ana Paula; Margalho, Cláudia; Rosado, Tiago; Barroso, MárioCannabis-based products have gained attention in recent years for their perceived therapeutic benefits (with cannabinoids such as THC and CBD) and widespread availability. However, these products often lack accurate labelling regarding their cannabinoid content. Our study, conducted with products available in Portugal, revealed significant discrepancies between label claims and actual cannabinoid compositions. ...
Impacto da Derivatização Química na Deteção de Metabolitos de Cocaína na presen...
Costa, Suzel; Rosendo, Luana; Barroso, Mário; Gallardo, EugeniaA toxicologia forense desempenha um papel crucial em investigações legais, proporcionando informações essenciais sobre a presença e o impacto de várias substâncias em amostras biológicas. No entanto, esta área enfrenta desafios significativos devido a artefactos e interferências que podem dificultar a interpretação dos resultados. Este estudo aborda os desafios analíticos decorrentes da presença simultânea de c...
Microextraction by packed sorbent clean-up for the determination of selected sy...
Simão, A.; Margalho, Cláudia; Dinis, P.; Andraus, M.; Barroso, Mário; Gallardo, E.Background and aims: The use of synthetic cathinones (SC), also known as "bath salts," has been increasing in recent years, leading to a growing concern about their effects on public health. Different clean-up approaches have already been studied by different authors. However, microextraction by packed sorbent (MEPS), a miniaturized form of solid-phase extraction, has not been explored extensively for the deter...
Comparative study of sample preparation procedures to determine the main compou...
Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Restolho, José; Fernández, Nicolás; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaIntroduction : Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. Objective :The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Methodology:Three sample pretreatment tech...
Opioid Monitoring in Clinical Settings: Strategies and Implications of Tailored...
Rosendo, Luana M.; Rosado, Tiago; Zandonai, Thomas; Rincon, Karem; Peiró, Ana M.; Barroso, Mário; Gallardo, EugeniaThis review emphasises the importance of opioid monitoring in clinical practice and advocates for a personalised approach based on pharmacogenetics. Beyond effectively managing pain, meticulous oversight is required to address concerns about side effects, specially due to opioid-crisis-related abuse and dependence. Various monitoring techniques, along with pharmacogenetic considerations, are critical for person...
Differentiation of selegiline metabolites and illicit methamphetamine and amphe...
Costa, Suzel; Rosendo, Luana M.; Barroso, Mário; Franco, João MiguelAbstract: Introduction: In forensic toxicology, distinguishing between pharmaceutical metabolites and illicit substances is crucial for accurate case interpretation. This study explores two post-mortem cases involving elderly individuals where methamphetamine and amphetamine were detected, raising initial concerns about illicit drug use. Aims: To demonstrate the application of liquid chromatography-tandem mass ...
Microextração em seringa empacotada (MEPS) como técnica de clean-up para a dete...
Simão, Ana; Dinis, Pedro; Margalho, Cláudia; Andraus, Maristela; Barroso, Mário; Gallardo, EugeniaIntrodução: O consumo de catinonas sintéticas, substâncias conhecidas como “bath salts”, tem crescido ao longo dos últimos anos tornando-se um problema de saúde pública. Várias metodologias têm sido desenvolvidas por diferentes autores. No entanto, a técnica miniaturizada – microextração em seringa empacotada (MEPS), tem sido pouco explorada para a determinação de catinonas sintéticas em cabelo. Objetivos: Nest...
Volumetric Absorptive Microsampling in Toxicology
Pires, Bruno; Catarro, Gonçalo; Soares, Sofia; Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Araujo, André R. T. S.; Gallardo, EugeniaVolumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and ...