81 documents found, page 1 of 9
Opioid detection and quantification in plasma and oral fluid by LC-MS/MS.
Rosendo, Luana M; Costa, Suzel; Simões, Susana; Franco, João; Serrano Gadea, Noelia; Escorial, Mónica; Toboso Ortega, Francisco JavierThe opioid crisis remains a significant public health concern, necessitating the development of sensitive and reliable analytical methods for drug detection. This study aimed to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous detection and quantification of fentanyl, buprenorphine, oxycodone, morphine, tramadol, and tapentadol in plasma and oral fluid...
Analysis of drugs of abuse and contaminants in individuals under drug surveilla...
Simão, A Y; Tokuyama, P Y; Zampieri, G; Rocha, V; Madruga, C; Isicawa, K; Cidade, L S; Almeida, K R; da Silva, N R; Barroso, Mário; Andraus, MIn this study, over 900 hair samples from individuals using drugs of abuse in São Paulo and Rio Grande do Sul, Brazil were analysed for classical drugs and new psychoactive substances (NPS) in hair samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the detection of some drugs (25B-NBOMe, 25C-NBOMe, 25E-NBOH, 2C-C, 2C-I, 3,4-MDPHP, 3-MeO-PCP, 5F-MDMB-PINACA, 5-MeO-DMT, ...
Characterization of Antidepressant Consumption in a Portuguese Inland Population.
Soares, Sofia; Rosado, Tiago; Santos, Vítor Hugo; Rei, Cristina; Amantegui, Patricia; Pissarra da Costa, António; Chaves, Telma; Valente, RitaMental disorders are a growing global concern, with depression being among the most prevalent. Portugal ranks second in antidepressant consumption within the OECD, following a threefold increase between 2000 and 2020. In inland regions such as Beira Interior, reduced healthcare services and distance from major hospitals further complicate access to care. This study analysed 142 patients from Beira Interior unde...
Determination of ketamine and norketamine in hair samples by µ-QuEChERS and gas...
Pelixo, Rodrigo; Barroso, Mário; Rosado, Tiago; Gallardo, EugeniaKetamine has gained popularity in Europe as a new psychoactive substance due to its dissociative effects, which are sought after by users at raves, for unprescribed treatment of psychological issues, and in drug-facilitated crimes. Forensic experts often face challenges in proving drug use, and hair offers distinct advantages as a sample, revealing both long-term consumption and recent abuse. However, due to it...
Chromatographic determination of antidepressants in plasma and saliva: Towards ...
Soares, Sofia; Rosendo, Luana; Fonseca, Suzana; Gonçalves, Nuno; Franco, João; da Costa, António Pissarra; Rosado, Tiago; Barroso, MárioDrug monitoring of antidepressants in plasma and oral fluid represents a valuable tool in clinical practice, enabling the optimisation of treatment efficacy and the reduction of adverse effects. Given the significant interindividual variability in antidepressant response-driven by factors such as metabolism, drug-drug interactions, and adherence to therapy-drug monitoring facilitates dose adjustment based on me...
Volumetric absorptive microsampling in toxicology
Pires, Bruno; Catarro, Gonçalo; Soares, Sofia; Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Araujo, André R T S; Gallardo, EugeniaVolumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and ...
Determination of Arylcyclohexylamines in Biological Specimens: Sensors and Samp...
Pelixo, Rodrigo; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoArylcyclohexylamine (ACH) compounds represent a predominant faction within new psychoactive substances. Due to their powerful dissociative effects, they are used in recreational contexts but also in situations of drug-facilitated sexual assault, and therefore, they are a constant target of analysis by forensic experts. In recent years, their consumption has been notably high, especially the use of ketamine, pre...
Determination of Antiepileptics in Biological Samples—A Review
Martinho, João; Simão, Ana Y.; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoEpilepsy remains a disease that affects many people around the world. With the development of new drugs to treat this condition, the importance of therapeutic drug monitoring continues to rise and remains a challenge for the medical community. This review article explores recent advances in the detection of antiepileptic drugs across various sample types commonly used for drug monitoring, with a focus on their ...
Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medica...
Pires, Bruno; Oliveira, Patrik; Simão, Ana Y.; Reis, João; Ramos, Sofia; Duarte, Ana Paula; Margalho, Cláudia; Rosado, Tiago; Barroso, MárioCannabis-based products have gained attention in recent years for their perceived therapeutic benefits (with cannabinoids such as THC and CBD) and widespread availability. However, these products often lack accurate labelling regarding their cannabinoid content. Our study, conducted with products available in Portugal, revealed significant discrepancies between label claims and actual cannabinoid compositions. ...
Impacto da Derivatização Química na Deteção de Metabolitos de Cocaína na presen...
Costa, Suzel; Rosendo, Luana; Barroso, Mário; Gallardo, EugeniaA toxicologia forense desempenha um papel crucial em investigações legais, proporcionando informações essenciais sobre a presença e o impacto de várias substâncias em amostras biológicas. No entanto, esta área enfrenta desafios significativos devido a artefactos e interferências que podem dificultar a interpretação dos resultados. Este estudo aborda os desafios analíticos decorrentes da presença simultânea de c...