Num período de cerca de 6 anos verificou-se uma importante mortalidade nos doentes com ELA; O FEV1Q revelou-se o melhor preditor de mortalidade de entre as variáveis analisadas; instabilidade poderá corresponder a um agravamento progressivo da ELA. Antes de aplicar estes resultados na prática clínica, é essencial realizar esta análise numa população maior para validar sua relevância e precisão.
Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emergin...
Although the impact of circadian timing on immunotherapy has yet to be integrated into clinical practice, chronoimmunotherapy is an emerging and promising field as circadian oscillations are observed in immune cell numbers as well as the expression of immunotherapy targets, e.g., programmed cell death protein-1 and its ligand programmed death ligand 1. Concurrent retrospective studies suggest that morning infus...