6 documents found, page 1 of 1
Development of the PraziCalc mobile device-app to calculate praziquantel dosage...
Viana, Agostinho Gonçalves; Coelho, André Luiz Gomes; Gazzinelli-Guimarães, Pedro Henrique; Phillips, Anna E.; Bartholomeu, Daniella Castanheira
Regulatory monocytes in helminth infections: insights from the modulation durin...
Mendes, Tiago Antônio de Oliveira; Passos, Lívia Silva Araújo; Gazzinelli-Guimarães, Pedro Henrique; Guimarães, Ana Clara GazzinelliWhile the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hookworm infection. Here, we report the profile of monocytes in human hookworm infections as a model to study the regulatory subpopulation of monocytes in helminth infections. Blood samples were collected from...
A new methodology for evaluation of nematode viability
Ferreira, Sebastião Rodrigo; Mendes, Tiago Antônio Oliveira; Bueno, Lilian Lacerda; Araújo, Jackson Victor de; Bartholomeu, Daniella CastanheiraNematodes infections are responsible for debilitating conditions and economic losses in domestic animals as well as livestock and are considered an important public health problem due to the high prevalence in humans. The nematode resistance for drugs has been reported for livestock, highlighting the importance for development of new anthelmintic compounds. The aim of the current study was to apply and compare ...
Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses nov...
Souza, Daniel Menezes; Mendes, Tiago Antônio de Oliveira; Gomes, Matheus de Souza; Cunha, João Luís Reis; Nagem, Ronaldo Alves PintoGold standard serological diagnostic methods focus on antigens that elicit a strong humoral immune response that is specific to a certain pathogen. In this study, we used bioinformatics approaches to identify linear B-cell epitopes that are conserved among Leishmania species but are divergent from the host species Homo sapiens and Canis familiaris and from Trypanosoma cruzi, the parasite that causes Chagas dise...
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli
Stoco, Patrícia Hermes; Wagner, Glauber; Talavera-Lopez, Carlos; Gerber, Alexandra; Zaha, Arnaldo; Thompson, Claudia ElizabethUniversidade Federal de Santa Catarina. Florianopolis, SC, Brazil; Universidade Federal de Santa Catarina. Florianopolis, SC, Brazil/Universidade do Oeste de Santa Catarina. Joaçaba, SC, Brazil; Karolinska Institutet. Science for Life Laboratory. Department of Cell and Molecular Biology. Stockholm, Sweden; Laboratorio Nacional de Computação Cientıfica. Petropolis, Rio de Janeiro, Brazil; Universidade Federal do...
Genetic profiling of Trypanosoma cruzi directly in infected tissues using neste...
Pimenta, Juliana Ramos; Freitas, Jorge Marcelo de; Duffy, Tomás; Bartholomeu, Daniella Castanheira; Oliveira, Riva de Paula; Chiari, EglerThe investigation of the importance of the genetics of Trypanosoma cruzi in determining the clinical course of Chagas disease will depend on precise characterisation of the parasites present in the tissue lesions. This can be adequately accomplished by the use of hypervariable nuclear markers such as microsatellites. However the unilocal nature of these loci and the scarcity of parasites in chronic lesions make...