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The impact of metal ions on the photo-antibacterial efficiency of metalloporphy...

Chaves, Inês; Morais, Filipe F. M.; Vieira, Cátia; Bartolomeu, Maria; Gomes, Ana T. P. C.; Faustino, M. Amparo F.; Neves, M. Graça P. M. S.

The influence of metal ions on the photochemical, photophysical, and antibacterial properties of three cationic porphyrin-triphenylphosphonium conjugates was investigated for the first time. Coordination with Zn(II), Pd(II) and Co(II) enabled fine-tuning of these conjugates properties, with Zn(II) complexes demonstrating particular promise. While Pd(II) and Co(II) complexes failed to generate singlet oxygen (1O...


Factors associated with the prevalence of apical periodontitis: an observationa...

Noites, Rita; Bartolomeu, Maria; Duarte, Ana Sofia; Perez, Alejandro; Cardoso, Miguel

Objectives: Apical periodontitis is a lesion of endodontic origin caused by an immune response to necrotic and infected dental pulp. Since apical periodontitis can persist after endodontic treatment, radiographic diagnosis is crucial. This study evaluates factors associated with the prevalence of apical periodontitis in a Portuguese population using the full-scale periapical index. Methods: A cross-sectional st...


Degree of contamination of gutta-percha points by Staphylococcus aureus (MRSA/M...

Teles, Ana Moura; Pina, Cristina; Cardoso, Inês Lopes; Tramontana, Antea; Cardoso, Miguel; Duarte, Ana Sofia; Bartolomeu, Maria; Noites, Rita

Methicillin-resistant Staphylococcus aureus (MRSA) is considered one of the most harmful bacteria to human health. Dentistry, like all healthcare disciplines, places great emphasis on preventing scenarios that may result in cross-infection. Although various tested and already used materials are suitable for filling the root canal system, Gutta-Percha (GP) remains the preferred and widely accepted gold standard....


Insight into the efficiency of microalgae’ lipidic extracts as photosensitizers...

Mendonça, Inês; Silva, Daniela; Conde, Tiago; Maurício, Tatiana; Cardoso, Helena; Pereira, Hugo; Bartolomeu, Maria; Vieira, Cátia; Domingues, M. Rosário

Antibacterial resistance causes around 1.27 million deaths annually around the globe and has been recognized as a top 3 priority health threat. Antimicrobial photodynamic therapy (aPDT) is considered a promising alternative to conventional antibiotic treatments. Algal lipid extracts have shown antibacterial effects when used as photosensitizers (PSs) in aPDT. In this work we assessed the photodynamic efficiency...


Wastewater disinfection with photodynamic treatment and evaluation of its ecoto...

Bartolomeu, Maria; Gomes, Thierry J.; Campos, Fábio; Vieira, Cátia; Loureiro, Susana; Neves, M. Graça P. M. S.; Faustino, M. Amparo F.

Research has demonstrated the presence of viruses in wastewater (WW), which can remain viable for a long period, posing potential health risks. Conventional WW treatment methods involving UV light, chlorine and ozone efficiently reduce microbial concentrations, however, they produce hazardous byproducts and microbial resistance that are detrimental to human health and the ecosystem. Hence, there is a need for n...


Insight into the efficiency of microalgae’ lipidic extracts as photosensitizers...

Mendonça, Inês; Silva, Daniela; Conde, Tiago; Maurício, Tatiana; Cardoso, Helena; Pereira, Hugo; Bartolomeu, Maria; Vieira, Cátia; Domingues, M. Rosário

Antibacterial resistance causes around 1.27 million deaths annually around the globe and has been recognized as a top 3 priority health threat. Antimicrobial photodynamic therapy (aPDT) is considered a promising alternative to conventional antibiotic treatments. Algal lipid extracts have shown antibacterial effects when used as photosensitizers (PSs) in aPDT. In this work we assessed the photodynamic efficiency...


Human Gingival Fibroblasts Response to Different Endodontic Sealers: An In Vitr...

Noites, Rita; Tavares, Inês; Cardoso, Miguel; Carreira, Isabel M.; Bartolomeu, Maria; Duarte, Ana S.; Ribeiro, Ilda Patrícia

Endodontic treatment aims to eliminate infection of the root canals and fill the dental pulp space. The biocompatibility studies of the sealers used in root canals obturation are crucial since they are applied in direct contact with periradicular tissues. Objective: The aim of this study was to evaluate the cytotoxicity of three root canal sealers—AH Plus, Bio MTA+, and Bio C sealer—on immortalized human gingiv...


O4 - Exploring the biological properties and regenerative potential of biomater...

Duarte, Ana Sofia; Correia, Bruna L.; Bartolomeu, Maria; Mendes, Karina; Gomes, Ana T. P. C.

Life expectancy has improved signifcantly and, along with the declining birthrate, has contributed to the aging of populations, especially in industrialized countries. Alas, aging is intrinsically associated with the incidence of health problems including bone and tooth loss that require suitable solutions to support the quality of life. To meet these demands, signifcant research eforts have been undertaken to ...


Enhancing bacterial photodynamic inactivation through combined action of potass...

Gamelas, Sara R. D.; Bartolomeu, Maria; Vieira, Cátia; Faustino, Maria A. F.; Tomé, João P. C.; Tomé, Augusto C.; Almeida, Adelaide

Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photos...


Deep Eutectic Solvents as alternative solvents in Antimicrobial Photodynamic Th...

Vieira, Cátia; Bartolomeu, Maria; Pedro, Sónia N.; Gomes, Ana T. P. C.; Dias, Cristina J.; Gamelas, Sara R. D.; Lourenço, Leandro M. O.


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