Ascites in ovarian carcinoma (OC) is one of the signs of peritoneal metastization and is often present at diagnosis in advanced stages and disease recurrence. This serous fluid can support the diagnosis and drained for symptomatic relief in advanced phases and subsequently discarded. In this context, ascitic fluid analysis is a unique opportunity to monitor the kinetics of tumor cells during disease progression...
Introduction: Mesonephric adenocarcinoma of the uterine cervix is a rare tumor, originating from remnants of the mesonephric duct. The differential diagnosis from other cervical carcinoma can be challenging. The existing data in the literature, regarding clinical history, diagnosis, prognosis and treatment is scarce.Methods: Four patients diagnosed with mesonephric adenocarcinoma of the cervix were treated at o...
Epithelial ovarian cancer is the most lethal gynecological malignancy and peritoneal metastases are the leading cause of morbidity and mortality. Malignant cells shed from primary tumor and float in ascitic fluid, as single cells or multicellular spheroids, and later implant on the peritoneal lining.
NTHL1 tumor syndrome is an autosomal recessive rare disease caused by biallelic inactivating variants in the NTHL1 gene and which presents a broad tumor spectrum. To contribute to the characterization of the phenotype of this syndrome, we studied 467 index patients by KASP assay or next-generation sequencing, including 228 patients with colorectal polyposis and 239 patients with familial/personal history of mul...
Accumulation of epicardial adipose tissue (EAT) is associated with coronary artery disease (CAD) and increased risk of coronary events in asymptomatic subjects and low-risk patients, suggesting that EAT promotes atherosclerosis in its early stage. Recent studies have shown that the presence of CAD affects the properties of adjacent EAT, leading to dynamic changes in the molecular players involved in the interpl...