Funding Information: This study was funded by Funda??o para a Ci?ncia e Tecnologia (FCT) - Doctoral Grant SFRH/BD/115382/2016, UID/04413/2020, UIDB/0006/2020 and UIDP/0006/2020. Funding Information: Funding This study was funded by Fundação para a Ciência e Tecnologia (FCT) -Doctoral Grant SFRH/BD/115382/2016, UID/04413/2020, UIDB/0006/2020 and UIDP/0006/2020. Competing interests None declared. Patient and publ...