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WHO global research priorities for antimicrobial resistance in human health

WHO Research Agenda for AMR in Human Health Collaborators; Bertagnolio, Silvia; Dobreva, Zlatina; Centner, Chad M.; Olaru, Ioana Diana; Donà, Daniele

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treat...


A multinational Delphi consensus to end the COVID-19 public health threat

COVID-19 Consensus Statement Panel; Lazarus, Jeffrey V.; Romero, Diana; Kopka, Christopher J.; Karim, Salim Abdool; Abu-Raddad, Laith J.

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific...


High proportions of asymptomatic and submicroscopic Plasmodium vivax infections...

Almeida, Anne Cristine Gomes; Kuehn, Andrea; Castro, Arthur J.M.; Vítor-Silva, Sheila; Figueiredo, Erick F.G.; Brasil, Larissa Wanderley

Background: Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomat...

Date: 2020   |   Origin: Oasisbr

Integrated vector management targeting Anopheles darlingi populations decreases...

Martins-Campos, Keillen M.; Pinheiro, Waléria Dasso; Vítor-Silva, Sheila; Siqueira, Andre M.; Melo, Gisely Cardoso de; Rodrigues, Íria C.

Background: Studies on vector behaviour should be conducted in order to evaluate the effectiveness of vector control measures on malaria protection in endemic areas of Latin America, where P. vivax predominates. This work aims to investigate the fauna of anopheline mosquitoes and verify the impact of integrated vector management in two colonization projects in the Careiro Municipality, Western Brazilian Amazon....

Date: 2020   |   Origin: Oasisbr

DEVELOPMENT AND CHARACTERIZATION OF MEDICAL PHANTOMS FOR ULTRASOUND IMAGING BAS...

Elvira, Luis; Duran, Carmen; Higuti, Ricardo T. [UNESP]; Tiago, Marcelo M.; Ibanez, Alberto; Parrilla, Montserrat; Valverde, Eva; Jimenez, Avier

Made available in DSpace on 2019-10-04T12:38:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-01; Instituto de Salud Carlos III; FEDER; This work presents an affordable and easily customizable methodology for phantom manufacturing, which can be used to mimic different anatomic organs and structures. This methodology is based on the use of polyvinyl alcohol-based cryogels as a physical substitute for...

Date: 2019   |   Origin: Oasisbr

G6PD deficiency in Latin America : systematic review on prevalence and variants

Monteiro, Wuelton Marcelo; Val, Fernando Fonseca de Almeida; Siqueira, André Machado; Franca, Gabriel Peixoto; Sampaio, Vanderson de Souza

Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Biblio...

Date: 2017   |   Origin: Oasisbr

Clinical complications of G6PD deficiency in Latin American and Caribbean popul...

Monteiro, Wuelton Marcelo; Franca, Gabriel Peixoto; Melo, Gisely Cardoso de; Queiroz, Amanda de Lourdes Maciel; Brito, Marcelo; Peixoto, Henry Maia

Background: Although G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce understanding of the burden of cli...

Date: 2017   |   Origin: Oasisbr

Filling gaps on ivermectin knowledge: effects on the survival and reproduction ...

Sampaio, Vanderson S.; Beltrán, Tatiana P.; Kobylinski, Kevin C.; Melo, Gisely C.; Lima, José B. P.; Silva, Sara G. M.; Rodriguez, Íria C.

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Diretoria de Ensino e Pesquisa. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Escola Superior de Ciências da Saúde. Manaus, AM, Brasil / Fundação de Vigilância em Saúde do Amazonas. Sala de Análise de Situação em Saúde. Manaus, AM, Brasil.; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Diretoria de Ensino e Pesquisa. Manaus, AM, Bras...

Date: 2017   |   Origin: Oasisbr

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