3 documents found, page 1 of 1
Disrupting SARS-CoV-2 Spike Protein Activity: A Virtual Screening and Binding A...
Queirós-Reis, L; Alvites, R; Maurício, AC; Brancale, A; Bassetto, M; Mesquita, JRSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that emerged in late 2019 and rapidly spread worldwide, causing the COVID-19 pandemic. The spike glycoprotein (S protein) plays a crucial role in viral target recognition and entry by interacting with angiotensin, converting enzyme 2 (ACE2), the functional receptor for the virus, via its receptor binding domain (RBD). The RBD av...
Exploring the Fatty Acid Binding Pocket in the SARS-CoV-2 Spike Protein - Confi...
Queirós-Reis, L; Mesquita, JR; Brancale, A; Bassetto, MSevere Acute Respiratory syndrome 2 (SARS-CoV-2) is a respiratory virus responsible for coronavirus disease 19 (COVID-19) and the still ongoing and unprecedented global pandemic. The key viral protein for cell infection is the spike glycoprotein, a surface-exposed fusion protein that both recognizes and mediates entry into host cells. Within the spike glycoprotein, a fatty acid binding pocket (FABP) was confirm...
SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implicati...
Queirós-Reis, L; Gomes da Silva, P; Gonçalves, J; Brancale, A; Bassetto, M; Mesquita, JRCoronavirus disease 19, or COVID-19, is an infection associated with an unprecedented worldwide pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has led to more than 215 million infected people and more than 4.5 million deaths worldwide. SARS-CoV-2 cell infection is initiated by a densely glycosylated spike (S) protein, a fusion protein, binding human angiotensin conver...