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Modulation of CD4 T cell function via CD6-targeting

Freitas, R; Basto, A; Almeida, S; Santos, RF; Gonçalves, CM; Corria-Osorio, J; Carvalho, T; Carmo, AM; Oliveira, V; Leon, K; Graca, L

In recent years molecules involved on the immune synapse became successful targets for therapeutic immune modulation. CD6 has been extensively studied, yet, results regarding CD6 biology have been controversial, in spite of the ubiquitous presence of this molecule on virtually all CD4 T cells. We investigated the outcome of murine and human antibodies targeting CD6 domain 1. We found that CD6-targeting had a ma...

Date: 2019   |   Origin: Repositório Aberto da Universidade do Porto
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