2 documents found, page 1 of 1
Decoding host-environment interactions in progressive pulmonary fibrosis: insig...
Meneses, Alexandra; Cardoso, Catarina G.; Coelho, David B.; Melo, Natália; Mota, Patrícia C.; Guimarães, Susana; Moura, Conceição S.; Carvalho, AndréInterstitial lung diseases (ILDs) comprise a heterogeneous group of parenchymal lung disorders characterized by diffuse infiltration of immune effector cells, fibroblasts, myofibroblasts, and extracellular matrix deposition at various pulmonary compartments. These conditions can progress to end-stage fibrosis, respiratory failure, and eventually, death. In 2020, we initiated the first national ILD registry and ...
Thyroid cancer: the quest for genetic susceptibility involving DNA repair genes
Santos, Luís S.; Gomes, Bruno Costa; Bastos, Hélder N.; Gil, Octávia M.; Azevedo, Ana Paula; Ferreira, Teresa C.; Limbert, Edward; Silva, Susana N.The incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To furth...