12 documents found, page 1 of 2
Unveiling common molecular pathways linked to ILDs with progressive fibrosing p...
Santos, Rita F.; Gonçalves, Melany; Mota, Patrícia Caetano; Cardoso, Catarina Gouveia; Coelho, Andreia L.; Sokhatska, Oksana; Beltrão, MaríliaProgressive fibrosing ILDs (PF-ILDs) comprise a heterogeneous group of lung disorders associated with high morbidity and mortality, that exhibit a continuous worsening phenotype despite standard treatment. Among PF-ILDs are pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (HP), involving complex interactions between host genetics and different environmental triggers, shaping the immune milieu ...
Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutat...
Fernandes, Maria Gabriela O.; Sousa, Catarina; Jacob, Maria; Almeida, Leonor; Santos, Vanessa; Araújo, David; Bastos, Hélder Novais; Magalhães, AdrianaOsimertinib efficacy in pre-treated patients with epidermal growth factor receptor (EGFR) T790M-mutated non-small cell lung cancer (NSCLC) has been demonstrated in clinical trials, but real-world data, particularly regarding resistance profile, remains limited. This study aims to analyze the resistance mechanisms acquired after treatment with Osimertinib. Clinical outcomes and molecular results from re-biopsie...
Hypersensitivity pneumonitis: antigen diversity and disease implications
Nogueira, R.; Melo, N.; Bastos, Hélder Novais; Martins, N.; Delgado, L.; Morais, A.; Mota, P. C.Hypersensitivity pneumonitis (HP) is an immune-mediated syndrome triggered by inhalation of a wide variety of allergens, to which an individual has previously been sensitized. More than 200 agents responsible for the disease have already been identified; however, HP occurs only in a small number of individuals exposed to causal antigens. The present report provides an overview of the role of antigen role in HP,...
The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflamma...
Bastos, Hélder Novais; Osório, Nuno S.; Gagneux, Sebastien; Comas, Iñaki; Saraiva, MargaridaThe already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our under...
Identification of human and pathogen molecular variants associated to tuberculo...
Bastos, Hélder NovaisTuberculosis (TB) imposes high human and economic tolls. One of the most striking features of TB is the variability of infection outcomes, which has been classically attributed to environmental and host determinants. More recently, studies uncovering Mycobacterium tuberculosis complex (MTBC) genomic diversity have shown the potential importance of pathogen-related factors to the disease pathogenesis. We approac...
Randomised short-term trial of high-span versus low-span APAP for treating slee...
Bastos, Hélder Novais; Cardoso, Ana Verónica; Castro, Ana Sofia; Gomes, Rita; Pinto, Tiago; Marinho, Anabela; Sucena, Maria; Almeida, JoãoPURPOSE: Auto-titrating continuous positive airway pressure (APAP) devices were developed to improve treatment efficacy and compliance in patients with obstructive sleep apnoea syndrome (OSAS). Since there are insufficient data on the optimal pressure range setting, we aimed to compare the adherence, efficacy and tolerability of treatment with high-span versus low-span APAP. METHODS: Seventy-six newly diagnosed...
The soluble pattern recognition receptor PTX3 links humoral innate and adaptive...
Chorny, Alejo; Casas‑Recasens, Sandra; Sintes, Jordi; Shan, Meimei; Polentarutti, Nadia; García‑Escudero, Ramón; Cunha, Cristina AmorimPentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptive immune system. ...
A prediction rule to stratify mortality risk of patients with pulmonary tubercu...
Bastos, Hélder Novais; Osório, Nuno S.; Castro, António G.; Ramos, Angélica; Carvalho, Teresa; Meira, Leonor; Araújo, David; Almeida, LeonorTuberculosis imposes high human and economic tolls, including in Europe. This study was conducted to develop a severity assessment tool for stratifying mortality risk in pulmonary tuberculosis (PTB) patients. A derivation cohort of 681 PTB cases was retrospectively reviewed to generate a model based on multiple logistic regression analysis of prognostic variables with 6-month mortality as the outcome measure. A...
Mechanical ventilation for the treatment of severe excessive dynamic airway col...
Bastos, Hélder Novais; Teixeira, Nelson; Redondo, Margarida; Gonçalves, Miguel; Sucena, Maria[Excerpt] We read with interest the case report by Ismael et al1 describing a patient with Sjo¨gren’s syndrome and cystic lung disease who could not be weaned from a ventilator due to severe central excessive dynamic airway collapse (EDAC) of the lower part of the trachea and proximal bronchi. EDAC corresponds to the expiratory bulging of the tracheobronchial wall without known airway structural abnormalities, ...
Influence of emphysema distribution on pulmonary function parameters in COPD pa...
Bastos, Hélder Novais; Neves, Inês; Redondo, Margarida; Cunha, Rui; Pereira, José Miguel; Magalhães, Adriana; Fernandes, GabrielaObjective: To evaluate the impact that the distribution of emphysema has on clinical and functional severity in patients with COPD. Methods: The distribution of the emphysema was analyzed in COPD patients, who were classified according to a 5-point visual classification system of lung CT findings. We assessed the influence of emphysema distribution type on the clinical and functional presentation of COPD. We al...