14 documents found, page 1 of 2
Predictors of survival and technical success of bronchoscopic interventions in ...
Freitas, C; Serino, M; Cardoso, C; Saleiro, S; Vaz, AP; Bastos, HN; Morais, A; Magalhães, A; Fernandes, GBackground: Malignant airway obstruction (MAO) leads to quality of life impairment and increased mortality. Interventional bronchoscopy allows airway patency restoring, leading to a better survival. We investigated predictors of survival and successful bronchoscopic intervention among MAO patients. Methods: This observational prospective study enrolled 100 patients who were newly diagnosed with MAO. Survival wa...
Management of Coronavirus Disease 2019 Patients With Lung Cancer: Experience Fr...
Coelho, DB; Santos, V; Araújo, D; Bastos, HN; Magalhães, A; Hespanhol, V; Queiroga, H; Martins, N; Fernandes, GBackground: Cancer patients appear to be at a higher risk of complications from coronavirus disease 2019 (COVID-19). Specific data related to lung cancer (LC) patient management, active treatment, and/or recent diagnosis are still very limited. Here, we aimed to investigate the clinical presentation, baseline features, and clinical outcomes of LC patients with COVID-19. Methods: A retrospective case study was p...
Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed...
Gomes, P; Bastos, HN; Carvalho, A; Lobo, A; Guimarães, A; Rodrigues, RS; Zin, WA; Carvalho, ARSObjective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD). Methods/Design: Patients with a post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < 0.70, without any other obstructive airway disease, who ...
Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis St...
Rocha, DMGC; Magalhães, C; Cá, B; Ramos, A; Carvalho, T; Comas, I; Guimarães, JT; Bastos, HN; Saraiva, M; Osório, NSWidespread and frequent resistance to the second-line tuberculosis (TB) medicine streptomycin, suggests ongoing transmission of low fitness cost streptomycin resistance mutations. To investigate this hypothesis, we studied a cohort of 681 individuals from a TB epidemic in Portugal. Whole-genome sequencing (WGS) analyses were combined with phenotypic growth studies in culture media and in mouse bone marrow deriv...
Recommendations for interventional pulmonology during COVID-19 outbreak: a cons...
Guedes, F; Boléo-Tomé, JP; Rodrigues, LV; Bastos, HN; Campainha, S; Santis, M; Mota, L; Bugalho, ACoronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by a novel SARS-CoV-2 pathogen. Its capacity for human-to-human transmission through respiratory droplets, coupled with a high-level of population mobility, has resulted in a rapid dissemination worldwide. Healthcare workers have been particularly exposed to the risk of infection and represent a significant proportion of COVID-19 cases...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic...
Sousa, J; Cá, B; Maceiras, AR; Simões-Costa, L; Fonseca, KL; Fernandes, AI; Ramos, A; Carvalho, T; Barros, L; Magalhães, C; Chiner-Oms, Á; Machado, HGenetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
Clinical profile and microbiological aetiology diagnosis in adult patients hosp...
Costa, MI; Cipriano, A; Santos, FV; Valdoleiros, SR; Furtado, I; Machado, A; Abreu, M; Bastos, HNEarly introduction of appropriate antibiotherapy is one of the major prognostic-modifying factors in community acquired pneumonia (CAP). Despite established guidelines for empirical therapy, several factors may influence etiology and, consequently, antibiotic choices. The aims of this study were to analyze the etiology of CAP in adults admitted to a northern Portugal University Hospital and evaluate the yield o...
Hypersensitivity pneumonitis: Main features characterization in a Portuguese co...
Santos, V; Martins, N; Sousa, C; Jacob, M; Padrão, E; Melo, N; Mota, PC; Bastos, HN; Guimarães, S; Moura, CS; Sokhatska, O; Cunha, R; Pereira, JHypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) which varies in prevalence across the world, depending on disease definition, diagnostic methods, exposure type and intensity, geographical environments, agricultural and industrial practices, and host risk factors. This study aimed to deepen knowledge about HP's clinical characteristics, diagnosis and functional and imaging features in a c...
Hypersensitivity pneumonitis: Antigen diversity and disease implications
Nogueira, R; Melo, N; Bastos, HN; Martins, N; Delgado, L; Morais, A; C, Mota, PHypersensitivity pneumonitis (HP) is an immune-mediated syndrome triggered by inhalation of a wide variety of allergens, to which an individual has previously been sensitized. More than 200 agents responsible for the disease have already been identified; however, HP occurs only in a small number of individuals exposed to causal antigens. The present report provides an overview of the role of antigen role in HP,...