17 documents found, page 1 of 2
An integrative sialomic analysis reveals molecules from Triatoma sordida (Hemip...
Praça, Yanna Reis; Santiago, Paula Beatriz; Charneau, Sébastien; Mandacaru, Samuel Coelho; Bastos, Izabela Marques Dourado; Bentes, Kaio Luís da SilvaTriatomines have evolved salivary glands that produce versatile molecules with various biological functions, including those leading their interactions with vertebrate hosts’ hemostatic and immunological systems. Here, using high-throughput transcriptomics and proteomics, we report the first sialome study on the synanthropic triatomine Triatoma sordida. As a result, 57,645,372 reads were assembled into 26,670 c...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the firs...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the fir...
Proteomic mapping of multifunctional complexes within Triatomine saliva
Santiago, Paula Beatriz; Charneau, Sébastien; Mandacaru, Samuel Coelho; Bentes, Kaio Luís da Silva; Bastos, Izabela Marques DouradoTriatomines are hematophagous insects that transmit Trypanosoma cruzi, the etiological agent of Chagas disease. This neglected tropical disease represents a global health issue as it is spreading worldwide. The saliva of Triatominae contains miscellaneous proteins crucial for blood feeding acquisition, counteracting host's hemostasis while performing vasodilatory, anti-platelet and anti-coagulant activities, be...
Triatomines : trypanosomatids, bacteria, and viruses potential vectors?
Vieira, Caroline Barreto; Praça, Yanna Reis; Bentes, Kaio Luís da Silva; Santiago, Paula Beatriz; Silva, Sofia Marcelino MartinsTriatominae bugs are the vectors of Chagas disease, a major concern to public health especially in Latin America, where vector-borne Chagas disease has undergone resurgence due mainly to diminished triatomine control in many endemic municipalities. Although the majority of Triatominae species occurs in the Americas, species belonging to the genus Linshcosteus occur in India, and species belonging to the Triatom...
Revealing a novel Otubain-Like Enzyme from Leishmania infantum with deubiquitin...
Azevedo, Clênia dos Santos; Guido, Bruna Cândido; Pereira, Jhonata L.; Nolasco, Diego O.; Corrêa, Rafael; Magalhães, Kelly Grace; Motta, Flávia NaderDeubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new therapeutic targets for leishmaniasis. Here we present the first characterization of a DUB from L. infantum, otubain (OtuLi), and its localization within parasite. The recombinant OtuL...
Insight into the Exoproteome of the tissue derived trypomastigote form of Trypa...
Queiroz, Rayner Myr Lauterjung; Ricart, Carlos André Ornelas; Machado, Mara Olimpia; Bastos, Izabela Marques Dourado; Santana, Jaime Martins deThe protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cel . The secreted/excreted protein repertoire released by T. cruzi try pomastigotes is crucial in host-pathogen interactions. In this study, mammalian tissue culture derived trypomastigotes (Ystrain) were used to characterize ethe exoproteome of ...
The activity of a Hexameric M17 Metallo-Aminopeptidase is associated with survi...
Corrêa, André França; Bastos, Izabela Marques Dourado; Neves, David; Kipnis, André; Kipnis, Ana Paula Junqueira; Santana, Jaime Martins deMycobacterium tuberculosis is one of the most prevalent human pathogens causing millions of deaths in the last years. Moreover, tuberculosis (TB) treatment has become increasingly challenging owing to the emergence of multidrug resistant M. tuberculosis strains. Thus, there is an immediate need for the development of new anti-TB drugs. Proteases appear to be a promising approach and may lead to shortened and ef...
Proteases of haematophagous arthropod vectors are involved in blood-feeding, yo...
Santiago, Paula Beatriz; Araújo, Carla Nunes de; Motta, Flávia Nader; Praça, Yanna Reis; Charneau, Sébastien; Bastos, Izabela Marques DouradoTicks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous arthropods considered vectors of human infectious diseases. While consuming blood to obtain the nutrients necessary to carry on life functions, these insects can transmit pathogenic microorganisms to the vertebrate host. Among the molecules related to the blood-feeding habit, proteases play an essential role. In this review,...
New binding site conformations of the dengue virus NS3 Protease accessed by mol...
Almeida, Hugo de; Bastos, Izabela Marques Dourado; Ribeiro, Bergmann Morais; Maigret, Bernard; Santana, Jaime Martins deDengue fever is caused by four distinct serotypes of the dengue virus (DENV1-4), and is estimated to affect over 500 million people every year. Presently, there are no vaccines or antiviral treatments for this disease. Among the possible targets to fight dengue fever is the viral NS3 protease (NS3PRO), which is in part responsible for viral processing and replication. It is now widely recognized that virtual sc...